扩张型心肌病与HLA—B^＊基因的多态性关系  

HLA-B^＊ gene polymorphism in patients with dilated cardiomyopathy

作　　者：金文成[1] 孙政育[1] 方胜[1] 曹峰林[1] 

机构地区：[1]哈尔滨市第一医院,150001

出　　处：《中国地方病学杂志》2007年第1期85-86,共2页Chinese Jouranl of Endemiology

摘　　要：目的探讨北方汉族人扩张型心肌病（dilated cardiomyopathy，DCM）遗传易感性与人类主要组织相容性复合体（HLA—B^＊）基因多态性的关系。方法采用聚合酶链反应和顺序特异性引物（PCR—SSP）基因多态性分析方法，对31例扩张型心肌病患者及29例无血缘关系健康人的HLA—B^＊各等位基因及亚基因进行检测分析。结果HLA—B^＊35基因与DCM呈正相关（相对危险度RR=3．9375，P〈0．05）．其他HLA—B^＊各等位基因未见异常，差异均无统计学意义（P〉0．05）。结论HLA—B^＊35基因可能是北方地区汉族人DCM的致病易感基因之一，为揭示DCM的发病机制中免疫遗传学所起的作用提供了重要信息和依据。Objective In order to study the correlation between HLA-B^＊ gene polymorphism and dilated cardiomyopathy （DCM）. Methods HLA-B^＊ gene polymorphism in 31 patients with DCM and 29 normal control subjects was analyzed using polymerase chain reaction-sequence specific primer（PCR-SSP） technique. Results The frequency of HLA-B^＊35 allele was significantly higher in patients than that in the controls with a relative risk （RR） in DCM patients of 3.9375 （P 〈 0.05）. Conclusions These findings further verify that immunogenetics plays a predominant pathogenetic role in a subset of DCM patients. Individuals carrying HLA-B^＊35 alleles may be susceptible to DCM.

关 键 词：心肌病 扩张型 聚合酶链反应 基因多态性 

分 类 号：R686[医药卫生—骨科学]