苦参碱对离体豚鼠右心室乳头肌的正性肌力作用  

The positive inotropic action of matrine to isolated right ventricle papillary muscles from guinea pig

作　　者：葛敏[1] 金朝俊[1] 王逸平[1] 孙伟康[1] 

机构地区：[1]上海长宁区中心医院,中国科学院上海药物研究所

出　　处：《宁波医学》1996年第4期208-209,共2页

摘　　要：苦参碱在１×１０－６～１×１０－３ｍｏｌ／Ｌ浓度范围内，有显著增加离体豚鼠右心室乳头状肌收缩力的作用，收缩力增加５０％时，苦参碱的浓度为１．３１３×１０－５ｍｏｌ／Ｌ，收缩力增加最大时（△Ｆｃｍａｘ），苦参碱的浓度为１×１０－３～３×１０－３ｍｏｌ／Ｌ，与阳性对照组氨力农相比，提示苦参碱对离体豚鼠乳头肌的正性肌力作用更强、致毒性浓度更高。The matrine enhanced the contractility of isolated guinea pig right venlrcalar papillary muscles in a concentraction range of 1×10-6～1× 10-3 mol/L.The concetraction of the matrine was 1.313 × 10-5 mol/L,which enhanced the amplitude of contractility to 50%. Enhancing the contractility upto the largest when it was 1 ×10-3～ 3 × 10-3 comparison with amrinone, the matrine gave more effectiveness on enhancing the contractility and greater toxicity to extracorporeal guinea pig papillary muscles.

关 键 词：苦参碱 乳头状肌 心肌收缩 氨联吡啶酮 

分 类 号：R542.2[医药卫生—心血管疾病] R972[医药卫生—内科学]