复方盐酸普鲁卡因对蟾蜍坐骨神经复合动作电位的影响  

THE EFFECT OF COMPOUND CHLOROPROCAINE ON COMPOUND ACTION POTE-NTAIL OF TOADS' NERVI ISCHIADICUS IN VITRO

作　　者：张业[1] 王嘉逊 孟庆芳 尹继业 焦文才[3] 李清漪[3] 杨秀珍[3] 

机构地区：[1]齐齐哈尔医学院中心实验室 [2]齐齐哈尔市第三制药厂 [3]齐齐哈尔医学院药理学教研室

出　　处：《齐齐哈尔医学院学报》1996年第4期241-244,共4页Journal of Qiqihar Medical University

摘　　要：采用细胞外电极引导动作电位方法,观察了4种浓度复方盐酸普鲁卡因,普鲁卡因和利多卡因对蟾蜍离体坐骨神经复合动作电位幅度的影响。结果表明:4种不同浓度复方盐酸普鲁卡因,普鲁卡因和利多卡因均可降低复合动作电位的幅度,呈剂效反应关系。其中1.9％复方盐酸普鲁卡因与同浓度普鲁卡因或利多卡因相比,前者可显著增加复合动作电位的衰减率,并呈时间反应关系(2分钟P<0.05,3～8分钟P<0.01)。复合动作电位完全消失的时间为8分钟,这一时间明显快于同浓度普鲁卡因和利多卡因。提示:1.9％的复方盐酸普鲁卡因可显著抑制复合动作电位的形成,神经阻断作用强于普鲁卡因或利多卡因单独使用。In this experiment, the effect of four different doses compound chloro-procaine, procaine and lidocaine on compound action potentail of toads nervi ischiadicus -were observed by the method of extrocellular inducting the compound action potentail in vitro. The results showed that amplitude of compound action potentail could be inhibited with four different doses compound chloriprocaine, procaine and lidocaine. Comparison 1.9% compound chloroprocaine with procaine and lidocaine, the attenuation rate could be increased with 1.9% compound chloroprocaine in manner-time ( 2 minutes was P<0.05 3-~8 minutes were P<0.01 ) , The time which compound action potentail completely disappeared was 8 minutes. The results indicated that the compound action potentail could be inhibited significantly by 1.9% compound chloroprocaine and the effect of nerve blocked was greater than procaine and lidocaine when it was used alone.

关 键 词：盐酸普鲁卡因 利多卡因 坐骨神经 动作电位 蟾蜍 

分 类 号：R965.2[医药卫生—药理学] R971.1[医药卫生—药学]