大剂量脉络宁治疗AMI再灌注损伤  

PREVENTION OF MIN TO AMI REINFUSION INJURY

作　　者：王维展[1] 岳爱菊[1] 张颖轩[1] 陈玉生[1] 耿建林[1] 郭丽娟[1] 樊慧丽[1] 张俊岭[1] 武长东 

机构地区：[1]河北省衡水市哈励逊国际和平医院内二科,河北省衡水市枣强县嘉会乡医院

出　　处：《河北医学》1996年第6期562-564,共3页Hebei Medicine

摘　　要：选择具有溶栓指征的急性心肌梗塞（ＡＭＩ）１０９例，施行尿激酶静脉溶栓治疗，冠脉再通８０例，分治疗组４２例，于溶栓前１０～３０ｍｉｎ给脉络宁４０～５０ｍｌ，并以此剂量每日１次连用７ｄ；设单用溶检治疗者３８例为对照组进行比较。结果：两组有效率分别为９７．６％和８４．２％，发生严重心衰３例（７．１％）和６例（１５．８％），发生再灌注心律失常（ＲＰＡ）１７例（４０．５％）和３０例（７８．９％），两组间差异显著。同时，脉络宁组在减少心肌氧耗量，缩小心肌梗塞面积，减少心肌酶的释放，提高左室射血功能方面都显著优于对照组。提示大剂量脉络宁具有抗ＡＭＩ再灌注性损伤的作用。Choicing 109 AMI patients who adapted the thrombolytic, We treated them with injecting urokinase, Among them there were 80 coronary urtery recirculation. Then we chose 42 patients to be injected MLN 40-50ml for 10-30 minutes befor the treatment and continued to use this dosage once a day. The rest 38 patients were to be observed, Then we compared the two groups, The result showed that 2 patients (3. 8%)and 6 patients(12.2%)died, 3 patients (7. 1%)and 6 patients(15. 8)presented serious heart failure. Besides, 17 patients(41. 5%) and 38 patients (77.6%)presented reinfusion arrhythmia. From these results we conduded that MLN could decrease the oxygen consumption of myoardium, decrease the area of myocardical infarction, decease the release of the serum myocardium enzyme.Furthermere it could increase the ejection function of the left-ventride. Ware, the big dosage MLN can produce the funtion which resist acutemyocardical infarction reinfusion injury.

关 键 词：脉络宁 AMI 溶栓治疗 再灌注性损伤 

分 类 号：R542.220.5[医药卫生—心血管疾病]