高氟饮水对8-12岁儿童牙齿及骨代谢指标的影响  

Effects of high fluoride in drinking water on children's teeth and osteogenesis

作　　者：马晓英[1] 崔留欣[1] 李世宏[2] 刘洋[3] 朱静媛[1] 程学敏[1] 巴月[1] 

机构地区：[1]郑州大学公共卫生学院环境卫生学教研室,郑州450001 [2]开封市疾病预防控制中心,开封475001 [3]河南省疾病预防控制中心,郑州450003

出　　处：《郑州大学学报（医学版）》2007年第1期60-62,共3页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省科技攻关基金资助项目524410067;河南省医学科技攻关基金资助项目200500106

摘　　要：目的：探讨高氟饮水对儿童牙齿及骨代谢指标的影响。方法：随机抽取62名高氟区和26名对照区的8—12岁儿童，检查氟斑牙患病率，并采集空腹静脉血，应用放免法测定血清骨钙素（BCP）和降钙素（CT）的水平。结果：高氟区儿童氟斑牙患病率为59．68％，对照区为3．85％；高氟区儿童血清BCP为（6．78±3．87）μg／L，对照区为（3．78±1．81）μg／L；高氟区儿童血清CT水平为（492．00±52．67）ng／L，对照馐为（948．57±74．72）ng／L，2区以上指标相比，差异均有统计学意义（P〈0．05）。结论：长期高氟饮水导致儿童氟斑牙患病率增高，且影响儿童骨代谢。Aim： To study the influence of high fluoride in drinking water on the children ＇s teeth and osteogenesis. Methods： A total of 62 childern from fluoride exposed area and 26 children from control area were chosen. The incidence of dental fluorosis was investigated. The serum levels of BGP and caleitonin （CT） were determined by radioimmunoassay. Results ： The incidences of dental fluorosis in fluoride exposed area and control area were 59.68% , 3.85% , respectively. The serum levels of BGP in the 2 areas were （6.78 ± 3.87） μg/L, （3.78 ± 1.81 ） μg/L, respectively. The serum levels of CT in the 2 areas were （492.00 ± 52.67） ng/L, （948.57 ± 74.72） ng/L, respectively. There were significant differences in the above indexes between the 2 areas （P 〈 0.05）. Conclusion; High fluoride in drinking water results in higher incidence of dental fluorosis, and also influence the ehildren＇s osteogenesis.

关 键 词：氟 氟斑牙 骨钙素 降钙素 

分 类 号：R995[医药卫生—毒理学]