心肌肌钙蛋白T在急性冠脉综合征诊断中的意义  

The diagnosis significance of cardiac troponin T in patient with acute coronary syndromes

作　　者：杨旭玲[1] 裴晓冬[1] 

机构地区：[1]沈阳医学院附属奉天医院循环内科,辽宁沈阳110024

出　　处：《中国实验诊断学》2007年第1期23-24,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨心肌肌钙蛋白T(CTnT)在急性冠脉综合征(ACS)诊断中的意义。方法同时测定入选患者血清的CTnT CK-MB水平。统计出阳性率和被确诊为急性心肌梗死(AMI)的人数,不稳定性心绞痛(UAP)的人数。然后比较其敏感性特异性和准确性,并观察AMI病人CTnT阳性持续时间。结果敏感性特异性和准确性分别为CT-nT89．2％86．7％88．5％；CK-MB78．6％、74．9％、76．1％。CTnT对AMI病人诊断的敏感性特异性和准确性与CK-MB比较有显著差别P<0．05。观察AMI病人CTnT阳性持续时间可达14天。结论在诊断AMI病人时,CTnT具有检测方法简便快速出现时间早敏感性特异性和准确性高诊断窗口时间长的优点,对AMI病人的早期诊断具有很好的价值,同时在ACS分型及危险因素判定中占有重要地位,适用于床边检验及急诊的快速诊断,是治疗的决策手段。Objective To evaluate the diagnosis significance of cardiac troponin T in patient with acute coronary syndromes. Methods The serum CTnT CK-MB density were measured in patients of coming into the CCU sickroom at the same tlme.Meanwhile-count the positive rate of CTnT-CK-MB and AMI-UAP sufferers having been diagnosed. Then to compare their sensitivity-distinguish ability-veracity.To observe the durative time of positive CTnT in AMI patients. Results sensitivity-distinguish ability-veracity were CTnT 89.2 %, 86.7 %, 88.5 % ;CK, MB 78.6 % ,74.9 % ,76.1%. The sensitivity-distinguish ability-veracity of CTnT for diagnosis of AMI-which was remarkable difference for CK-MB . The time of positive CTnT in AMI patients last fourteen days. Conclusion CTnT has the better value in early diagnosing AMI . Such as conveniuent and high-spced-carly produce-higher sensitivity-distinguish ability-veracity and longer diagnosis time windows.There is a important position in the classify of ACS and the detenniue of dtmgemus factor. It is a important decision of treat.

关 键 词：肌钙蛋白T(CInT) 肌酸磷酸激酶同功酶MB(CK-MB) 急性心肌梗死(AMI) 不稳定性心绞痛(UAP) 急性 冠脉综合征(ACS) 

分 类 号：R541.4[医药卫生—心血管疾病]