加味补阳还五汤对次声暴露下小鼠学习记忆能力的影响  

Protection by Jiawei Buyang Huanwu Decoction from the Harm of Infrasound (16 Hz,130 dB)in Mice

作　　者：范建中[1] 杨俊峰[1] 陈景藻[2] 谭晓明[1] 

机构地区：[1]南方医科大学南方医院康复医学科,广东广州市510515 [2]第四军医大学西京医院康复医学科,陕西西安市710032

出　　处：《中国康复理论与实践》2007年第1期35-36,共2页Chinese Journal of Rehabilitation Theory and Practice

基　　金：军队"十五"指令性课题(01L071)

摘　　要：目的观察加味补阳还五汤对16Hz(8Hz),130dB次声暴露下小鼠学习记忆能力的影响。方法将学习记忆能力相近的80只BALB/c小鼠分为16Hz组和8Hz组,其中每组再分为空白对照组、次声对照组以及次声加用药组(根据用药剂量的不同又分高、中、低剂量组),处理14d后测试其学习记忆能力的变化。结果次声对照组的学习记忆能力降低(P<0·05),16Hz用药组较次声对照组的逃逸时间明显缩短(P<0·01),8Hz用药组较次声对照组的逃逸时间无显著性差异,各剂量组之间未见显著性差异。结论16Hz(8Hz),130dB次声暴露14d(2h/d)可引起小鼠学习记忆能力的下降。加味补阳还五汤可以提高16Hz次声暴露后小鼠的学习记忆能力。Objective To study the effects of Jiawei Buyang Huanwu Decoction on learning and memory abilities of mice exposed to 130 dB infrasound （16 Hz）. Methods 80 BALB/c mice were divided into blank-control group, infrasound-control group, infrasound and drug-treated group （it was divided into 3 sub groups according to dose）. Learning and memory abilities were measured 14 d later. Results Compared with blank-control group, learning and memory abilities decreased （P 〈 0.05） in infrasound control group. Compared with infrasound-control group, learning and memory abilities increased（P〈0.01） in infrasound and drug treated group. Conclusion 16 Hz,130 dB infrasound could damage learning and memory abilities. Jiawei Buyang Huanwu Decoction could protect mice from learning and memory harm exposed to the infrasound.

关 键 词：次声 加味补阳还五汤 学习记忆 小鼠 

分 类 号：R594.9[医药卫生—内科学]