脑卒中与肺炎衣原体感染的相关性  

Correlation between cerebral stroke and Chlamydia pneumoniae infection

作　　者：刘爱民[1] 徐坚[2] 余竹元[3] 

机构地区：[1]复旦大学附属金山医院神经内科,上海200540 [2]复旦大学附属金山医院职防科,上海200540 [3]复旦大学附属中山医院内科免疫室,上海200032

出　　处：《中国人兽共患病学报》2007年第1期63-65,共3页Chinese Journal of Zoonoses

摘　　要：目的探索肺炎衣原体(Cpn)慢性感染与脑卒中之间的关系。方法2002年3月-2006年1月来复旦大学附属金山医院就诊的25岁至72岁脑卒中患者60例为病例组,选择60名性别、年龄和种族等与病例组相匹配的无脑卒中者为对照组,用微量免疫荧光法检测血清中Cpn抗体(IgA、IgG),并比较血清总胆固醇(TC),甘油三酯(TG)水平的差异。结果在脑卒中组和对照组血清中,Cpn IgA的阳性检出率分别为75.0%(45/60)和38.3%(23/60),P<0.001;Cpn IgG的阳性检出率分别为58.3%(35/60)和43.3%(26/60),P>0.05。脑卒中组TC(5.75±0.74 mmol/L)高于对照组(4.62±0.76mmol/L),具有统计学意义(P<0.05),TG水平差别无统计学意义。结论肺炎衣原体慢性感染的血清学证据与脑卒中危险有关,IgA滴度比IgG可能是更好的危险标记物。这一发现表明,脑卒中与Cpn之间有着临床的紧密关联,有关病因学的关系,有待进一步研究。To explore the relationship between cerebral stroke and Chlamydia pneumoniae infection, 60 patients suffered from cerebral stroke, aged from 25 to 70 and enrolled at Jinshan Hospital from Mar. 2002 to Jan 2006, were selected for study and matched for age and sex to 60 controls. Titers of C. pneumoniae-specific IgA and IgG antibodies in both patients with cerebral stroke and controls were determined by means of micro-immunofluorescence assay and the differences in the levels of total cholesterol （TC） and triglyceride （TG） in serum were compared between patients and controls. It was found that the C. pneumoniae-speeific IgA antibody was detected in 45 patients with cerebral stroke （75.0%） and 23 controls （38.3%） （P〈 0. 001）, while the C. pneumoniae-specific IgG antibody was detected in 35 patients with cerebral stroke （58.3 %） and 26 controis （43.3%）, （P〉0.05）. Also the serum lipid profiles were compared in these two groups, in which the total serum cholesterol concentration was higher in patients with cerebral stroke than that in the controls （5.75±0.74 versus 4.62±0. 76）, but there was no difference in the triglyceride concentration between these two groups. From the above mentioned results, it is evident that the serological evidence of the chronic infection with C. pneumoniae is associated to the risk of cerebral stroke and the titer of IgA level may be a better marker for the risk of cerebral stroke than that of IgG.

关 键 词：脑卒中 肺炎衣原体 微量免疫荧光 

分 类 号：R374[医药卫生—病原生物学]