常用对比剂流率下脑CT灌注量计算方法的改良  

An improved method of quantitative assessment of regional cerebral blood flows by perfusion CT at the general infusion rate

作　　者：胡春洪[1] 吴庆德[1] 王雪元[1] 诸伟[1] 沈海林[1] 傅引弟[1] 丁乙[1] 

机构地区：[1]苏州大学附属第一医院影像中心,215006

出　　处：《中华放射学杂志》2007年第1期22-25,共4页Chinese Journal of Radiology

基　　金：江苏省医学重点人才基金(RC2003096);江苏省科技厅社会发展项目(BS2003630)

摘　　要：目的改进常用对比剂流率(<5 ml/s)下基于最大斜率模型的脑 CT 灌注量的计算方法。方法 8名健康志愿者行脑部多层螺旋 CT 灌注成像检查。分别利用机配灌注分析软件(传统法)和自编灌注分析软件(改良法)计算正常人脑灰、白质脑血流值(CBF),并进行比较。结果改良法和传统法得出的正常脑灰质血流量分别为(70.0±7.6)、(34.9±1.8)ml·min^(-1)·100 g^(-1),两种方法间差异有统计学意义(t=12.64,P<0.01);改良法和传统法得出的正常脑白质血流量分别为(24.9±3.7)、(12.9±1.8)ml·min^(-1)·100 g^(-1),两者差异亦有统计学意义(t=8.23,P<0.01)。结论改良后算法有望弥补常用对比剂流率下传统方法的缺陷,测得的 CBF 更接近于实际值。Objective To improve the conventional method of quantitative assessment of-regional cerebral blood flows （rCBF） by a perfusion CT study based on maximal slope model at the general infusion rate （〈 5 ml/s）. Methods Multislice CT perfusion imaging studies were performed in eight healthy adult volunteers. Regional cerebral flows of the gray matter and the white matter were calculated respectively with dedicated perfusion software of the scanner （ the conventional method） and our self-made software （ the improved one）. Results Normal rCBFs in the gray matter calculated with our improved method and with the conventional one were （70. 0 ± 7. 6 ） and （ 34. 9 ±1.8 ）ml·min^-1·100g^-1 respectively. There was significant difference between two methods （ t = 12. 64, P 〈 0. 01 ）. Normal rCBFs calculated with our improved method and with the conventional method were （24. 9 ± 3.7） and （12. 9 ± 1.8 ） ml·min^-1·100g^-1 respectively in the white matter. The normal rCBFs in the white matter showed significant difference between two methods（ t = 8.23,P 〈 0. 01 ）. Conclusion The improved method can be used to remedy the limitation of the conventional method efficiently, with which normal rCBFs are more accurate.

关 键 词：体层摄影术 X线计算机 脑 血液动力学 

分 类 号：R816.1[医药卫生—放射医学]