食管鳞癌组织中MIFmRNA的表达及其意义  

Expression and Significance of macrophage migration inhibitory factor mRNA in esophagus squamous cell carcinoma

作　　者：赵劲松[1] 廖克龙[1] 

机构地区：[1]第三军医大学附属西南医院胸心外科,重庆400038

出　　处：《重庆医科大学学报》2007年第1期52-54,共3页Journal of Chongqing Medical University

摘　　要：目的:探讨巨噬细胞移动抑制因子(MIF)mRNA在食管鳞癌及正常食管组织中的表达及其与临床病理特征的关系。方法:采用逆转录-聚合酶链反应(RT-PCR)法检测MIFmRNA在80例手术切除的食管鳞癌组织及正常食管组织中的表达。结果:MIFmRNA表达率在食管鳞癌中为85%(68/80),而在正常食管组织中为15%(15/80),有显著性差异(P<0.01)。MIFmRNA的阳性表达率与肿瘤细胞分化程度及TNM分期有关(P<0.05),而与患者年龄、性别、肿瘤大小以及有无淋巴结转移无关(P>0.05)。结论:MIFmRNA的高水平表达说明其参与了食管鳞癌的发病机制.并将可能为食管鳞癌的早期诊断和治疗提供一种新的手段。Objective：To explore the mRNA expression of macrophage migration inhibitory factor （MIF）in esophageal squamous cell carcinoma and its relationship with the clinical pathologic characteristics of that carcinoma.Methods：The expressions of MIF mRNA in esophageal carcinoma tissues and normal esophageal tissues were detected by RT-PCR in eighty patients.Results：MIF mRNA expression rate in esophageal carcinoma was 85%（68/80）,while in the normal esophageal tissues it was 15%（15/80）.the difference was significant （P 〈 0.01）.The positive expression rate of MIF mRNA was correlated with differentiation degree and TNM stage of carcinoma（P〈0.05）,but not with patient age,patient sex,or lymph node metastasis（P〉0.05）.Conclusion：Increased MIFmRNA expression contributed to carcinogenesis of esophageal squamous cell carcinoma,which might provide a new way for early diagnosis and therapy of esophageal carcinoma.

关 键 词：巨噬细胞移动抑制因子 逆转录聚合酶链反应 食管鳞癌 

分 类 号：R655[医药卫生—外科学]