丹参对肝硬化上消化道大出血患者体内脂质过氧化状态的影响  

Effects of Salvia miltiorrhiza bunge injection on the status of lipid peroxidation in liver cirrhosis patients with massive upper gastrointestinal hemorrhage

作　　者：和水祥[1] 徐俊丽[1] 赵刚[1] 王艳丽[1] 符寒[1] 李红霞[1] 苌新明[1] 

机构地区：[1]西安交通大学医学院第一附属医院消化内科,陕西省西安市710061

出　　处：《世界华人消化杂志》2007年第2期181-184,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨肝硬化上消化道大出血患者体内脂质过氧化状态的变化及丹参注射液对其的影响.方法:肝硬化上消化道大出血患者91例,随机分为丹参注射液治组(n=36)和传统治疗组(n=55).分别测定患者血中超氧化物岐化酶(SOD)活性和过氧化脂质(LPO)含量.结果:传统治疗组患者血中LPO含量在出血后明显增加,72h左右达最高峰(11.0±4.1 nmol/L),较出血前或12h内(7.8±3.3 nmol/L)明显升高(P<0.01),1wk后开始下降,4wk后可不同程度恢复.而经丹参注射液治疗的患者血中LPO含量亦于72h左右达最高峰,但变化幅度较小(9.9±4.6nmol/L vs 7.8±3.1nmol/L,P<0.05),恢复较快.两组SOD活性变化与LPO含量变化相反,72h降至最小值(传统治疗组:0.87±0.2 nkat/L vs 1.3±0.2 nkat/L,P<0.01;丹参注射液治组:0.9±0.3 nkat/L vs 1.4±0.2 nkat/L,P<0.01),4 wk后可不同程度恢复.丹参注射液治疗组患者的预后明显优于传统治疗组(P<0.01),且Child-Pugh B级者优于C级(P<0.05).结论:丹参注射液可提高机体的抗氧化能力,改善肝硬化上消化道大出血患者的预后.AIM： To study the changes of lipid peroxidation in liver cirrhosis patients with massive upper gastrointestinal hemorrhage and the effects of Salvia miltiorrhiza bunge （SMB） injection on the changes. METHODS： Ninety-one liver cirrhosis patients with massive upper gastrointestinal hemorrhage were randomly divided into group A （n = 36） and B （n = 55）, treated with SMB injection and traditional method, respectively. The dynamic changes of plasma lipid peroxide （LPO） content and superoxide dismutase （SOD） activity were determined in the patients of both groups. RESULTS： The plasma content of LPO in group B was obviously increased and reached its peak at the 72^th h （11.0 ± 4.1 nmol/L）, significantly higher than that at the 12^th h （7.8 ± 3.3 nmol/L, P 〈 0.01）, but it declined in the 1^th week, and recovered in the 4^th week to some extent. LPO content also reached its peak at 72^th h in group A, with a lower-extent change （9.9 ± 4.6 nmol/L vs 7.8 ± 3.1 nmol/L,P 〈 0.05） and rapid recovery. The activities of SOD in both groups were decreased and reached their lowest values at the 72^th h （group A： 0.9 ± 0.3 nkat/L vs 1.4±0.2 nkat/L,P 〈 0.01; group B： 0.87 ± 0.2 nkat/L vs 1.3 ± 0.2 nkat/L, P 〈 0.01）. They also recovered in the 4^th wk with different degrees. The prognosis of patients in group A was superior to that in group B, which was correlated with Child-Pugh classification （P〈0.05）. CONCLUSION： SMB injection can enhance the antioxidant capability in vivo and improve the prognosis of liver cirrhosis patients with mas- sive upper gastrointestinal hemorrhage.

关 键 词：丹参注射液 肝硬化 上消化道大出血 过氧化脂质 超氧化物岐化酶 

分 类 号：R259[医药卫生—中西医结合]