2种溶血性试验方法在复方参芍注射剂研究中的应用  

Two Hemolysis Tests Used in Study of Compound Shenshao Injection

作　　者：崔亚男[1] 王东凯[1] 邱志斌[1] 

机构地区：[1]沈阳药科大学药学院,沈阳市110015

出　　处：《中国药房》2007年第3期182-183,共2页China Pharmacy

摘　　要：目的比较常规体外试管法及改进的体外溶血试验法在中药注射剂中的应用。方法根据药理实验方法学规定的溶血性试验方法,以复方参芍注射剂为研究对象进行试验。结果改进的体外溶血法能更准确地判断复方参芍注射剂的溶血浓度。结论对于用于静脉注射的新中药制剂,建议使用改进的体外溶血法评价其溶血安全性。OBJECTIVE： To compare the application of the improved hemolysis test and the routine in vitro test tube method in compound Shenshao injection. METHODS： Compound Shenshao injection was studied through adoption of the hemolysis test stipulated by the pharmacologic empirical methodology. RESULTS： Improved in vitro hemolysis test can determine the concentration of compound Shenshao injection more accurately. CONCLUSION： It is advisable that improved in vitro hemolysis test be adopted to evaluate the hemolysis safety of newly-developed Chinese medicines for intravenous injection.

关 键 词：肉眼观察法 分光光度法 溶血性 复方参芍注射剂 

分 类 号：R965.2[医药卫生—药理学] R286[医药卫生—药学]