原发性高血压病病人血管重构与中医证型相关关系的研究  

The Relation between Vascular Remodeling in Patients with Essential Hypertension and Syndrome Identified by Traditional Chinese Medicine

作　　者：王英杰[1] 胡婉英[2] 

机构地区：[1]上海曙光医院 [2]上海中医药大学附属曙光医院

出　　处：《中西医结合心脑血管病杂志》2007年第1期11-13,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的以中医证型和血管重构为切入点,比较各证型血管重构的差异,根据中医证候群,判断血管重构的发生情况及寻找相关因素。方法以脉压、动脉弹性指数C1和C2,颈动脉内膜-中层厚度对血管重构进行评估;同时测定胰岛素抵抗指数、炎性高敏C反应蛋白(hsCRP)。结果肝阳上亢组发病年龄较小,病程较短;痰湿壅盛组体重指数(BMI)、hsCRP数值明显增高;校正年龄、病程后,痰湿壅盛组、肝肾阴虚组与阴阳两虚组C1和C2下降较明显,在痰湿壅盛组以hsCRP为因变量,脉压、胰岛素抵抗指数(HOMA-IR)、BMI、病程为自变量,逐步回归分析,BMI、HOMA-IR进入方程与hsCRP独立相关。结论中医的肝肾亏虚和痰、湿可能共同参与了血管重构,在临床上可以通过中医证候群来判定血管重构的情况,并初步判断血管重构的相关因素。Objective To evaluate the relation between vasvular remodeling in patients （ r with essential hypertension and syndrome identified by Traditional Chinese Medicine. Methods One hundred and fifty pts and 120 normal subjects were studyed. The C1 （ large artery index）and C2（small artery index） were recorded. The hs-CEP IP and BMI were collected. Results The typeractivity of liver - yang patterns is common in younger patients or in the early phase; In abundant accumulation of phlegm - dampness patterns groups, hsCRP and BMI were higher obviously than the other groups,Adjusted age and course,C1 and C2 were decreased in abundant accumulation of phlegmdampness. patterns,deficiency of liver and kidney yinpatterns,deficiency of bothyin and yang patterns; In abundant accumulation of phlegmdampness patterns groups, hsCRP was takedas dependent variable, PP, HOMA-IR, BMI course takedas independent variable, regressive analysis step by step, BMI, HOMA-IR entered regression equation, showed that there was independent correlation with hsCRP. Conclusion Phlegm-dampness or deficiency of liver and kidney yin perhaps aggravate the vascular remodeling. By clinical signs, such as syndrome patterns of TCM, we could judge remodeling and correlate factors.

关 键 词：高血压 血管重构 中医证型 胰岛素抵抗 C-反应蛋白 

分 类 号：R259[医药卫生—中西医结合]