儿童真菌感染常见病原菌及药敏试验研究  

Study of common pathogen and antifungal susceptibility testing in pediatric patients with fungal infection

作　　者：张波[1] 贺丹[1] 王爽[2] 张云峰[1] 杨艳秋 王丽[1] 横山耕治[4] 

机构地区：[1]吉林大学基础医学院病原生物学教研室,130021 [2]吉林大学二院皮肤科 [3]吉大一院儿科 [4]日本千叶大学真菌医学研究中心

出　　处：《中国妇幼保健》2007年第1期78-81,共4页Maternal and Child Health Care of China

基　　金：国家自然科学基金资助项目(项目编号30571773);吉林省科技发展计划重点资助项目20050205-3

摘　　要：目的：探讨小儿真菌感染的病原菌特点、分布、易感因素、防治对策。方法：统计50例儿童真菌感染病例，通过真菌培养、涂片鉴定、药敏试验，分析小儿真菌感染病原体特点、发病高危因素及肪治措施。结果：感染菌种以白色念珠菌最常见，感染部位以皮肤和消化道多见。抗真菌药物氟康唑、5-氟胞嘧啶、伊曲康唑、两性霉素B、酮康唑的敏感率为88．0％。96．0％，结论：小儿真菌感染与原发、继发性免疫功能低下、化疗、激素、抗生素应用密切相关。这5种抗真菌药物是治疗儿科真菌感染的有效药物。Objective： To investigate the characteristics and distribution of pathogen, susceptible factors, measures for prevention and treatment in pediatric fungal infection. Methods： A retrospective study of 50 children with fungal infection was made. Characteristics of infection pathogen, the infection site, related susceptible factors, prevention and treatment were analyzed by fungal culture, microscope identification and antifungal susceptibility testing. Results： The most common infection pathogen was Candida species. The common infection sites were skin and digestive tract. These anti - fungal medicine susceptibility of 50 fungi strains to fluconazole, 5 - flucytosine, itracoinazole, amphotcnicin B and ketoconazole were 88. 0% -96.0%. Conclusion： Pediatric fungal infection is related closely to multifactors, such as primary or secondary immunodeficiency, chemotherapeutic drugs, hormone and antibiotics. The above 5 anti -fungal drugs are effective in therapy of pediatric fungal infection.

关 键 词：儿童 真菌感染 药敏试验 

分 类 号：R379[医药卫生—病原生物学]