HPLC法检查小剂量阿司匹林片中的游离水杨酸  

Test for Free Salicylic Acid in Small Dose of Aspirin Tablets by HPLC

作　　者：庄舒翔[1] 吴雨川[1] 

机构地区：[1]黑龙江省药品检验所,哈尔滨150001

出　　处：《黑龙江医药》2007年第1期9-10,共2页Heilongjiang Medicine journal

摘　　要：目的:建立HPLC法检查小剂量阿司匹林片中游离水杨酸的方法。方法:以十八烷基硅烷键合硅胶为填充剂;乙腈-四氢呋喃-冰醋酸-水(23:5:5:61)为流动相;检测波长280nm。结果:水杨酸在0．1063～53．15μg/ml r=0．9999范围内呈良好线性,精密度试验:RSD=0．64％(n=6)。结论:本方法准确、可靠。可用于检查小剂量阿司匹林片中的游离水杨酸。Objectire： To establish a HPLC method for testing free salicylic acid in small dose of aspirin tablets. Methods： The test was conducted on a DiamonsirIM C18 column （ 150 × 4.6mm, 5um ）, using actetonitrile - tetrahydrofuran -glacial HAc- H2O（23：5： 5： 61） as mobile phase and a UV detector at 280nm.Results：The linear range for the method was 0.1063- 53 .15μg·ml^-1（r= 0.9999） .The method was precise with RSD of 0.64% for within-day variation（n= 6） .Condusion： Anaccurate and rapid HPLC method for testing free salicylic acid in small dose of aspirin tablets is established.

关 键 词：小剂量阿司匹林片 游离水杨酸 

分 类 号：R927.1[医药卫生—药学]