伊贝沙坦、缬沙坦和氯沙坦对高血压左室肥厚的影响  

Effectiveness of Irbesartan,Valsartan,Losartan on Left Ventricular Hypertrophy Caused by Hypertension

作　　者：李晓东[1] 贾晨红[1] 扬智勇[1] 曹乾[1] 孙立平[1] 

机构地区：[1]中国医科大学附属第二医院心内科,辽宁沈阳110004

出　　处：《中国误诊学杂志》2007年第1期3-5,共3页Chinese Journal of Misdiagnostics

摘　　要：目的:比较伊贝沙坦、缬沙坦和氯沙坦对高血压左室肥厚的疗效。方法:选择130例高血压患者,随机分为3组,分别给予伊贝沙坦、缬沙坦和氯沙坦治疗6个月。观察治疗前后舒张末期室间隔厚度(IV ST)、舒张末期左室后壁厚度(PW T)、左室重量(LVM)、左室重量指数(LVM I)的变化及24 h平均血压的变化。结果:三组治疗前后血压明显下降(P<0.01),IV ST、PW T、LVM和LVM I明显下降(P<0.01),三组间比较差异无显著性(P>0.05)。结论:伊贝沙坦、缬沙坦和氯沙坦均可有效的降低血压,并明显改善心室肥厚。Objective：To compare the effectiveness of Irbesartan, Valsartan,Losartan on left ventricular hypertrophy caused by hypertension. Method： 130 patients with hypertension were randomly divided into 3 groups and each group was administrated Irbesartan,Valsartan,Losartan respectively for 6 months. Interventricular septum thickness （IVST） at the end of dialation, posterior wall thickness （PWT） at the end of dialation, left ventricular weight （LVW）, left ventricular weight index（LVWI）,mean blood pressure of 24 hours were investigated before and after administration. Result：There were significantly decreased blood pressure,IVST,PWT, LVW, LVWI （P〈0.01） after the treatment. Statistical differeace among the three groups were not observed. Conclusion ：Irbesartan,Valsartan,Losartan are all effective on lowing blood pressure and reversing left ventricular hypertrophy.

关 键 词：高血压/并发症 高血压/药物疗法 肥大 左心室 联苯化合物/治疗应用 四唑类/治疗应用 缬氨酸/类似物和衍生物 洛沙坦/治疗应用 

分 类 号：R544.106[医药卫生—心血管疾病]