蓝刺头茎叶中化学成分的分离与鉴定  

Chemical constituents from the stem and leaves of Echinops latifolius Tausch.

作　　者：张玉伟[1] 李铣[1] 孟大利[1] 汪毅[1] 

机构地区：[1]沈阳药科大学中药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2007年第1期23-25,共3页Journal of Shenyang Pharmaceutical University

摘　　要：目的对蓝刺头茎叶进行化学成分研究。方法采用硅胶柱色谱、Sephadex LH 20柱色谱、制备薄层色谱等方法分离化学成分,1H NMR1、3C NMR等方法进行结构鉴定。结果从蓝刺头茎叶中分离并鉴定了8个化合物,分别为:β谷甾醇(βsitosterol,1)、蒲公英萜醇乙酸酯(taraxerol ac-etate,2)、木栓酮(friedelin,3)、胡萝卜苷(daucosterol,4)、5(丁烯3炔1)联噻吩[5(but 3 en 1ynyl)2,2′bithiophene,5]、α三联噻吩(αterthienyl,6)、卡多帕亭(cardopatine,7)、异卡多帕亭(iso-cardopatine,8)。结论化合物3为首次从该属植物中分离得到。Objective To study the chemical constituents from the stem and leaves of Echinops latifolius Tausch. Methods The constituents were isolated by silica gel column chromatography, sephadex LH-20, prepeared TLC and the ^1H-NMR, ^13C-NMR spectroscopic analysis were employed for the structural elucidation. Results Compounds 1 - 8 were obtained and their structures were identified as β-sitosterol, taraxerol acetate, friedelin, daucosterol, 5- （but-3-en-l-ynyl）-2, 2＇-bithiophene, 5 α-terthienyl, cardopatine and isocardopatine respectively. Conclusions Compound 3 is isolated from Echinops latifolius Tausch. for the first time.

关 键 词：蓝刺头 茎叶 化学成分 结构鉴定 

分 类 号：R932[医药卫生—生药学] R914[医药卫生—药学]