螺内酯和氯沙坦对心肌梗死大鼠血流动力学及心肌胶原重构的影响  

Effects of spironolactone and losartan on hemodynamics and myocardial collagen remodeling after myocardial infarction in rats.

作　　者：刘刚[1] 周晓东[1] 籍振国[1] 刘超[1] 刘焱[1] 刘坤申[1] 李兰芳[2] 

机构地区：[1]河北医科大学附属第一医院心内科,河北石家庄050031 [2]河北省医科院药理实验室,河北石家庄050031

出　　处：《中国实用内科杂志》2007年第2期114-116,共3页Chinese Journal of Practical Internal Medicine

基　　金：河北省自然科学基金(303478)

摘　　要：目的研究螺内酯、氯沙坦对大鼠心肌梗死后血流动力学和心肌胶原重建的影响。方法于2005年10月至2006年3月在河北省医科院药理实验室,结扎大鼠冠状动脉左前降支制作心肌梗死模型,随机分为假手术组、安慰剂组、螺内酯组、氯沙坦组、螺内酯+氯沙坦组。第2、6周观察平均动脉压(MBP)、左室舒张末压(LVEDP)、左室相对重量、非梗死区心肌胶原含量及Ⅰ/Ⅲ型胶原蛋白比值。结果安慰剂组较假手术组LVEDP升高,心肌胶原含量及Ⅰ/Ⅲ型胶原蛋白比值增加。第2周,氯沙坦组和螺内酯+氯沙坦组较安慰剂组MBP、LV-EDP、心肌胶原含量及Ⅰ/Ⅲ型胶原蛋白比值下降。第6周,螺内酯组、氯沙坦组及螺内酯+氯沙坦组与安慰剂组相比较LVEDP、心肌胶原含量及Ⅰ/Ⅲ型胶原蛋白比值均下降,螺内酯+氯沙坦组较螺内酯组、氯沙坦组心肌胶原含量降低更显著。结论螺内酯、氯沙坦均可改善心肌梗死后血流动力学,抑制胶原增生。两药联合应用可充分抑制胶原重建作用。Objective To observe the effects of spironolactone and losartan interventions on homodynamics and collagen remodeling after myocardial infarction. Methods During 2005.10 to 2006.3 ,we have done the study at Hebei Academy of Medical Sciences. The myocardial infarction model was induced by ligating the left anterior descending coronary artery. Then the rats were randomly divided into sham, placebo, spironolactone, losartan and losartan ＋ spironolactone groups. Mean blood pressure（ MBP）, left ventficular end-diastolic pressure（ LVEDP）, interstitial collagen content and the ratio of type Ⅰ and Ⅲ collagen of non-infarction zone were assessed at the 2nd and the 6th week. Results Significant increase in LVEDP, collagen content, and the ratio of type Ⅰ and Ⅲ collagen（ P 〈 0. 05）were found in the placebo-treated infracted rats as compared with sham group at the 2nd and the 6th week. MBP, LVEDP and the ratio of type Ⅰ and Ⅲ collagen contents were all significantly decreased in lasartan treated group and the combination treated group than placebo-treated rats at the 2nd week. At the 6th week, LVEDP,collagen contents, the ratio of typeⅠ and Ⅲ collagen were all significantly decreased in spironolactone treated rats, losartan treated rats and the combination treated rats. However, MBP, LVEDP, collagen contents,the ratio of type Ⅰ and Ⅲ collagen were lower in the combination treated rats compared with spironolactone treated rats and lasartan treated rats. Conclusion Spironolactone and losartan can coordinate and improve the cardiac hemodynamics and the left ventricular collagen remodeling after myocardial infarction in rats.

关 键 词：心肌梗死 螺内酯 氯沙坦 血流动力学 心肌重构 

分 类 号：R5[医药卫生—内科学]