复方丹参滴丸防治大鼠早期糖尿病肾脏损害的研究  

Effect of Compound Danshen Drop Pills on early stage diabetic nephropathy in rat models

作　　者：李佑生[1] 王文健[1] 马宇滢[1] 刘毅[1] 何春燕[1] 何燕铭[1] 陈伟华[1] 应健[1] 

机构地区：[1]复旦大学附属华山医院中医科复旦大学中西医结合研究所,上海200040

出　　处：《中成药》2007年第1期40-44,共5页Chinese Traditional Patent Medicine

摘　　要：目的:考察复方丹参滴丸对大鼠早期糖尿病肾脏损害的疗效。方法:采用高糖高脂喂饲加低剂量STZ建立大鼠2型糖尿病肾病模型,给予复方丹参滴丸治疗12周,动态观察血糖及尿微量白蛋白尿等指标。结果:复方丹参滴丸大剂量时可降低血糖、减少尿微量白蛋白、减轻肾脏肥大、减少尿量,而中低剂量可降低血清甘油三酯水平,疗效优于氯沙坦。结论:复方丹参滴丸大剂量时有改善实验性大鼠2型糖尿病肾脏病变,主要是改善微量白蛋白尿的作用。AIM ： To explore the effect of Compound Danshen Drop Pills （CDDP） on early stage of diabetic nephropathy in rat models. METHODS ： Diabetic nephropathy of type 2 diabetes rat model was established by feeding with high glucose high fat diet with low dose STZ injection. Rats were treated with CDDP then and blood glu- cose, urinary micro-albumin and other targets were measured at different time points. RESULTS： High dose of CDDP decreased blood glucose level, reduced urinary micro-albumin, glomerular hypertrophy and urinary volume. Middle and low dose of CDDP decreased blood triglyceride level. These effects were better than Losartan. CONCLUSION： High dose of CDDP could ameliorate diabetic nephropathy in type 2 diabetes rat models, and the main effect was reducing urinary miero-albuimn.

关 键 词：复方丹参滴丸 糖尿病肾病 微量白蛋白尿 胰岛紊抵抗 大鼠 

分 类 号：R285.6[医药卫生—中药学]