复方鬼箭羽汤改善高血压病胰岛素抵抗和血液流变学的临床研究  

Clinical Study of Compound Ramulus Euonymi Decoction in Improving Insulin Resistance and Hemorheological Parameters of Hypertension Patients

作　　者：彭利[1] 李忠业[2] 鲍宜桂[1] 

机构地区：[1]广西柳州市中医院,广西柳州545001 [2]广西中医学院第一临床医学院,广西南宁530023

出　　处：《广州中医药大学学报》2007年第1期14-17,共4页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】观察复方鬼箭羽汤(由鬼箭羽、葛根、丹参、当归、制大黄、黄连等药物组成)的降压和改善高血压病胰岛素抵抗及血液流变学的作用。【方法】将符合纳入标准的80例高血压病患者随机分为试验组(42例)和对照组(38例),试验组予口服复方鬼箭羽汤加卡托普利,对照组仅服用卡托普利,两组疗程均为6周,观察治疗前后2组空腹血糖(FPG)、空腹血清胰岛素(FINS)、胰岛素敏感指数(ISI)和血压、血液流变学的变化。【结果】治疗后两组患者的收缩压(SBP)及舒张压(DBP)均较治疗前有显著性降低(P<0.01),且FINS水平呈显著性降低(P<0.05或P<0.01),ISI呈显著性升高(P<0.05或P<0.01);治疗后两组的血液流变学各项指标也均有显著性改善(P<0.05或P<0.01)。两组治疗后比较,试验组FINS水平低于对照组(P<0.05),ISI水平高于对照组(P<0.01),血液流变学各项指标的改善也优于对照组(P<0.05),但其降压作用与对照组相仿(P>0.05)。【结论】复方鬼箭羽汤对高血压病胰岛素抵抗有确切的改善作用,而且能够改善高血压病患者异常的血液流变学指标。[ Objective] To observe the effect of Compound Ramulus Euonymi Decoction （CRED, mainly composed of Ramulus Euonymi, Radix Puerariae, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix et Rhizoma Rhei, Rhizoma Coptidis, etc. ） in improving insulin resistance and hemorheological parameters of hypertension patients. [Methods] Eighty hypertension patients were randomized into two groups. Group A （N =42） was treated with CRED and Captopril Tablets and group B （N = 38） with Captopril Tablets only. The treatment lasted 6 weeks. After treatment, the changes of fasting plasma glucose （FPG）, fasting serum insulin （FINS）, insulin sensitivity index （ISI）, blood pressure and hemorheological parameters were observed. [ Results ] After treatment, systolic blood pressure （SBP） and diastolic blood pressure （DBP） decreased （P 〈0.01）, FINS decreased and ISI increased （P 〈0.05 or P 〈0.01）, and the hemorheological parameters were also improved （P 〈 0.05 or P 〈 0.01） as compared with those before treatment. FINS was lower （P 〈0.05） and ISI higher in group A than those in group B （P 〈0.01）, and the improvement of hemorheological parameters in group A was superior to that in group B （ P 〈 0.05）, but the effect on decreasing blood pressure was similar in the two groups （ P 〉 0.05）. [ Conclusion] CRED has a certain effect in improving insulin resistance and hemorheological parameters of hypertension patients.

关 键 词：高血压/中药疗法 复方鬼箭羽汤/治疗应用 胰岛素抵抗 血液流变学 

分 类 号：R259.441[医药卫生—中西医结合]