绝缘体介电电泳细胞分离器件数值分析和优化  

Numerical Simulation and Optimization of Insulator-Based Dielectrophoresis Devices for Biopartical Separation

作　　者：丁英涛[1] 王金鹏[2] 王喆垚[2] 仲顺安[1] 

机构地区：[1]北京理工大学信息科学技术学院,北京100081 [2]清华大学微电子学研究所,北京100084

出　　处：《传感技术学报》2007年第1期50-53,共4页Chinese Journal of Sensors and Actuators

摘　　要：绝缘体介电电泳(iDEP)利用微流体管道中均匀绝缘柱阵列产生介电电泳(DEP)所需要的非均匀电场,实现微全分析系统(μTAS)和芯片实验室(LOC)中细胞等生物粒子的分离.对这种新型的iDEP器件进行理论分析,建立了数值计算方法.基于有限元数值计算理论,利用Ansys软件,计算了细胞的介电电泳力,验证了iDEP的富集原理,对iDEP器件的介质形状、尺寸、间距和微管道长度等参数进行了优化,提出了设计准则.选用间距10μm,圆形,微管道长度3550μm的5×5绝缘柱阵列,器件性能最优.Insulator-based （electrodeless） dielectrophoresis （iDEP） is an innovative approach which is widely used as biopartical separation in the micro total analysis systems （μTAS）. The non-uniform electric field needed for dielectrophoresis （DEP） is produced by microarray insulators in the microchannels according to the new method. Based on the numerical simulation, iDEP microdevices were analyzed and functions were demonstrated. The electrical field generated by iDEP microdevices and DEP force experienced by cells in the microdevices were calculated using Finite Element Method （FEM）. Furthermore, design parameters of iDEP microdevices, such as dielectric shape, dielectric size, dielectric distance, were optimized and a set of optimal parameters were given for a specific application. The performance is the best under 10μm in distance, 3550μm in length and 5×5 circle insulator-array.

关 键 词：微全分析系统 绝缘介电电泳 数值计算 微流体 微阵列 

分 类 号：TN402[电子电信—微电子学与固体电子学]