葛根素对局灶性脑缺血再灌注模型大鼠脑组织水肿及神经细胞Na^+-K^+-ATPase、Ca^(2+)-ATPase活性的影响  

The Influence of Puerarin on the Brain Edema and the Activity of Na^+-K^+-ATPase,Ca^(2+)-ATPase in Neuron of Ischemia-Reperfusion Rats

作　　者：王玉[1] 朱慧渊[1] 郭莹[1] 韩进[1] 万海同[1] 

机构地区：[1]浙江中医药大学心脑血管病研究所,杭州310053

出　　处：《中国中医急症》2007年第1期70-71,共2页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(No.30371789);浙江省自然科学基金项目(No.Z204424;Y405171)

摘　　要：目的探讨葛根素对脑缺血再灌注损伤保护作用的机制。方法采用大鼠大脑中动脉栓塞模型(MCAO),观察葛根素对脑缺血再灌注脑组织水肿及神经细胞Na+-K+-ATPase、Ca2+-ATPase活性的影响。结果葛根素能明显降低MCAO大鼠脑含水量,提高Na+-K+-ATPase、Ca2+-ATPase活性。结论大鼠MCAO后脑组织水肿明显,ATPase活性降低;葛根素可以减轻此类损伤,对脑组织具有保护作用。Objective： To explore the protective mechanism of Puerarin on cerebral ischemia - reperfusion injury. Methods： The ischemia -reperfusion model rats was induced by means of middle cerebral artery occlusian（MCAO）, the brain edema and Na ^＋ - K^ ＋ - ATPase, Ca^2 ＋ATPase activity in neuron were measured to study the effect of Perarin against cerebral ischemia - reperfusion injury. Results： Puerarin can significant decrease the brain edema in rats induced by MCAO, and increase the activity of Na ^＋ K ^＋ - ATPase, Ca^2＋ - APTase. Conclusions： The brain edama is obviously increased and the activity of ATPase is obviously decreased after MCAO. Puerarin can alleviate the injuriy and has the neuro -protective effect against ischemia -reperfusion injury.

关 键 词：葛根素 脑缺血再灌注 MCAO 大鼠 

分 类 号：R285.5[医药卫生—中药学]