胎盘感染人巨细胞病毒与胎儿生长发育关系探讨  

Exploring on the correlation between HCMV infection of placenta and fetal growth.

作　　者：陈素华[1] 闻良珍[1] 冯玲[1] 曾万江[1] 王志新[1] 凌霞珍[1] 

机构地区：[1]同济医科大学附属同济医院

出　　处：《中国实用妇科与产科杂志》1996年第5期277-278,共2页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：应用聚合酶链反应技术检测４４例人巨细胞病毒（ｈｕｍａｎｃｙｔｏｍｅｇａｌｏｖｉｒｕｓ，ＨＣＭＶ）ＩｇＭ阳性孕妇的胎盘组织ＨＣＭＶＤＮＡ，并观察其足月新生儿身体发育状况。发现胎盘ＨＣＭＶ感染时新生儿身体发育明显落后（Ｐ＜０．０５）。另外，检测８例先天性畸形儿的内脏及其母体胎盘组织ＨＣＭＶＤＮＡ结果皆为阳性。证实胎盘ＨＣＭＶ感染影响胎儿生长发育，严重时可导致先天性畸形。bjective:To determine the correlation between the HCMV infction of placenta and fetal growth.Design:HCMV DNA of placenta of 44 pregnant women whose serum HCMV IgM antibody were positive were studied by PCR technique.Result:The results showed that the weight and the height of the newborns whose maternal placental HCMV DNA were positive were 2 93±0.45kg and 50.00±2.48cm respectively,and their growth were significantly slow.While the HCMV DNA of fetal organs and placenta in 8 congenital malformed newborns were all positive.Conclusion:HCMV infection of placenta can reduce the speed offetal growth and cause fetal abnormality.

关 键 词：巨细胞病毒 胎盘 胎儿生长发育 

分 类 号：R714.43[医药卫生—妇产科学] R714.51[医药卫生—临床医学]