活化蛋白C抵抗与胎儿生长受限的相关性研究  

The study on the correlation between the activated protein C resistance and fetal growth restriction.

作　　者：冯梅[1] 冯玲[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,湖北武汉430030

出　　处：《中国优生与遗传杂志》2007年第1期55-56,35,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的检测胎儿生长受限(FGR)母体血浆蛋白C敏感率(APCsr),了解活化蛋白C抵抗(APC-R)在原因不明FGR患者中的发生情况,并进一步探讨APC-R引起胎盘血管微小血栓形成而导致FGR的发生机制。方法采用APTT±APC法检测20例原因不明FGR患者,35例正常待产妇的APCsr。结果20例FGR患者中APCsr≤2者12例,阳性率达60%,而正常妊娠组APC-R阳性率31.4%,两组差异有显著性(P<0.05)。且FGR组APCsr均值(1.94±0.32)明显低于正常妊娠组(2.24±0.28)。相关分析显示,APCsr值与新生儿出生体重呈正相关(r=0.531)。结论APC-R在FGR患者中有较高的发生率,APC-R引起的胎盘微小血栓形成可能是导致FGR的另一重要因素。Objective： We examined the activated protein C sensitive ratio of pregnancies complicating with fetal growth restriction to find out the incidence of the activated protein C resistance and explore the mechanism through which APC - R cause to minute thrombus within the placenta, finally introduce fetal growth restriction. Methods： An activated partial thromboplastin time （APTr） - based assay, examine APCsr of 20 pregnancies with idiophathic fetal growth restriction and 30 normal pregnancies. Result： The mean value of APC - SR of FGR group is lower than normal pregnant women＇s, and the difference is significant （ P 〈 0. 05 ）, and birth weight of infants correlate directly with APCsr. Conclusion： Activated protein C resistance may contribute to risk of fetal growth restriction.

关 键 词：活化蛋白C抵抗 胎儿生长受限 血栓形成 妊娠病理 

分 类 号：R714.5[医药卫生—妇产科学]