产前应用乙型肝炎免疫球蛋白对于阻断乙肝母婴宫内传播作用的Meta分析  

Meta-analzsis on the effect of hepatitis B immunoglobulin on the interruption of hepatitis B virus intrauterine infection during late pregnancy.

作　　者：范祎[1] 肖小敏[1] 

机构地区：[1]暨南大学附属第一医院妇产科,广东广州510632

出　　处：《中国优生与遗传杂志》2007年第1期62-64,共3页Chinese Journal of Birth Health & Heredity

基　　金：广东省科技计划项目(项目编号:2005B34201010)

摘　　要：目的综合评价孕晚期应用乙型肝炎免疫球蛋白（hepatitis B immunoglobulin，HBIG）阻断乙肝病毒母婴宫内传播作用的有效性。方法对国内外12篇有关孕晚期使用乙型肝炎免疫球蛋白阻断母婴宫内传播的随机化对照临床试验结果。进行了固定效应模型的Meta分析。结果孕晚期应用乙肝免疫球蛋白可以显著阻断乙肝病毒的母婴宫内传播（Z=7．15，P〈0．00001）合并OR值为0．26，0R95％CI为0．18-0．37。结论孕晚期应用乙肝免疫球蛋白可以显著阻断乙肝病毒的宫内传播。Objective： To evaluate the effiecy of hepatitis B immunoglobulin （HBIG） on interrupting hepatitis B virus intrauterine transmission during late pregnancy. Methods： The resuhs of 12 case -control studies about using hepatitis B immunoglobulin （HBIG） to interrupt hepatitis B vires intrauterine transmission during late pregnancy were analyzed by Review Manager 4. 2 Random effect model of Meta - analysis method was used. Results ： HBIG can significandy decrease the intrauterine transmission rate of hepatitis B virus when administered to pregnant women regularly during late pregnancy （Z= 7. 15, P 〈 0. 00001 ）, The pools OR value is 0. 26, and the 95% Confidence Interval of OR value is 0. 18 -0. 37. Conclusion： HBIG can obviously decrease the intrauterine transmission rate of hepatitis B virus when in fecting it during late pregnancy.

关 键 词：乙型肝炎免疫球蛋白(HBIG) 乙型肝炎病毒 宫内传播 META分析 

分 类 号：R714.25[医药卫生—妇产科学]