重组人类红细胞生成素及长期间隔补铁防治早产儿贫血  

Treat prematurity anemia with erythropoietin and long-term interval iron.

作　　者：何丽红[1] 陈爱贞[1] 吴丽娜[1] 邝露莎[1] 

机构地区：[1]佛山市第一人民医院儿科,广东佛山528000

出　　处：《中国优生与遗传杂志》2007年第1期78-80,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨早期应用重组人类红细胞生成素（rHuEPO）和铁剂，后期长期间隔补铁防治早产儿贫血的疗效，及对早产儿生长发育、智能方面的影响。方法2002．2～2005．2入住本院NICU的早产儿共179例．随机分为治疗组64例、对照组57例、空白组58例，治疗组应用rHuEPO（生后第1周开始，750IU·kg^-1·w^-1，共6w）及铁剂（生后14d开始，元素铁2mg·kg^-1·d^-1，共6w），以后每周补铁1次（元素铁2mg·kg^-1），直至12月龄。对照组生后应用rHuEPO6w及铁剂6w同治疗组，方法同治疗组，不继续补铁。空白组不用rHuEPO及铁剂治疗。观察3组早产儿HGB、血清铁蛋白（SF）、体重、身高动态变化至12月龄，6、12月龄进行DDST智能筛查。结果治疗组、对照组12w内HGB较空白组明显升高（P〈0．01），4-12月龄治疗纽HGB较对照组、空白组明显升高（P〈0．01），3-12月龄治疗组SF较对照组、空白组明显升高（P〈0．01），6-12月龄治疗组体重、身高较对照组、空白组明显增长（P〈0．01、P〈0．05）。6、12月龄DDST治疗组较对照组、空白组明显优胜（P〈0．05）。结论早产儿生后早期应用rHuEPO和铁剂可以减轻早产儿早期贫血，继续长期间隔补铁，可以有效防治早产儿后期贫血，改善生长发育。Objective： To explore the curative effect treated with erythropoietin and iron in early stage and long - term interval iron in later stage for the prematurity anemia. The treatment affected grow and intelligence was explored. Methods： 179 preterm infants were randomly assigned to treated group （64 eases） or contrasted group （57 cases） or blank group （58 cases）. The treated group were given rHuEPO （750·kg^-1·w^-1, for 6 weeks） from the first week of life and elemental iron （2mg·kg^-1·d^-1, for 6 weeks） from the fourteenth day of life, They were given long - term interval iron after above treatment to 12 months old. The contrasted group were given rHuEPO for 6 weeks and iron for 6 weeks, They weren＇t given iron continue. The blank group weren＇t given rHuEPO and iron. Three groups were observed to 12 months old concerning HGB, SF, weight, height, intelligence. Results： The hemoglobin was significantly raised than the blank group in the treated group and the contrasted group for 12 weeks old （ P 〈0. 01 ）. The hemoglobin was significantly raised in the treated group from 4 to 12 months old （ P 〈0. 01 ）. Serum ferritin was significantly raised in the treated group from 3 to 12 months old （ P 〈0. 01）. The weight and height was significantly raised in the treated group from 6 to 12 months old （ P 〈 0. 01, P 〈 0. 05）. The intelligence with DDST was significantly superior in the treated group （ P 〈 0. 05）. Conclusion ： It can lighten prematurity early stage anemia that rHuEPO and iron is given early. It is efficacious concerning long - term interval iron for prematurity later stage anemia and grow.

关 键 词：早产儿 贫血 红细胞生成素 铁 

分 类 号：R722.6[医药卫生—儿科]