降糖灵对实验性糖尿病大鼠糖脂代谢的影响  

Effects of Jiang-Tang-Ling on Glucose and Lipid Metabolism in Diabetic Rats

作　　者：张志平[1] 邹丽宜[2] 吴铁[2] 吴怡[1] 尤婷婷[2] 

机构地区：[1]广东医学院医药科技开发中心,广东湛江524023 [2]广东医学院药理教研室,广东湛江524023

出　　处：《时珍国医国药》2007年第1期9-11,共3页Lishizhen Medicine and Materia Medica Research

基　　金：广东省科技计划资助项目(No.2003C30501)

摘　　要：目的探讨中药复方降糖灵对糖尿病大鼠的血糖和血脂代谢的作用。方法用灌喂脂肪乳剂4周后,腹腔注射0.2%链脲佐菌素(STZ)30 mg/kg的方法造成大鼠糖尿病模型后,用含生药量1 g/m l的降糖灵灌胃进行治疗,并同时用二甲双胍按1 mg/kg灌胃作为阳性药物治疗,1次/d,连续6周。实验结束后观察降糖灵和二甲双胍对大鼠体重、血浆胰岛素、蛋白组成和含量变化、血脂含量和组成变化以及肝糖原的含量变化等。结果各组大鼠的体重变化差异不大(P>0.05),二甲双胍和降糖灵能明显降低糖尿病大鼠的血糖。二甲双胍能降低胆固醇的含量,但是不能增加高密度脂蛋白、白蛋白、血浆胰岛素和肝糖原的含量。降糖灵可将升高高密度脂蛋白、白蛋白、血浆胰岛素和肝糖原的含量,同时能降低胆固醇和甘油三酯的含量(P<0.05)。结论降糖灵组能有效地降低高脂高糖大鼠的血糖和血脂,其作用机制可能与其促进胰岛释放胰岛素、增加肝糖原的合成和改善脂代谢有关。Objective To study the effects of Jiang - Tang - Ling on glucose and lipid metabolism in diabetic rats. Methods Rats were fed with high sugar and fat food for 4 weeks, then 0. 2% streptozotocin （STZ ,30 mg/kg^-1） was injected intraperitoneally to induce hyperglycemia and hyperlipemla. The model rats were administrated with Jiang - Tang - Ling（ 1 g/ml） or metformin（1 mg/kg）, once a day for 6 weeks. After the experiment, the body weight, the blood glucose, the plasma llpids, the plasma albumen,insulin, and liver hepatin were observed. Results The body weight had no difference among the groups（P 〉 0. 05 ）. Jiang - Tang - Ling and mefformin decreased the blood sugar and cholesterin, Jiang - Tang - Ling also increased HDL - C, albumin, plasma insulin and liver hepatin, and decreased plasma triacyl glycerol（ P 〈 0. 05 ）. Conclusion Jiang- TangLing can adjust the blood glucose and lipid effectively, and the mechanism maybe related to enhancc the insulin release, increase liver glycogen synthesis and improve lipids metabolism.

关 键 词：链脲佐菌素 糖尿病 高脂血症 大鼠 

分 类 号：R285.5[医药卫生—中药学]