止嗽立效胶囊的毒理学研究  

Toxicologic Study on Zhisoulixiao Capsule

作　　者：王卉[1] 尤春来[1] 穆培[1] 李云兴[1] 

机构地区：[1]辽宁中医药大学药理教研室,辽宁沈阳110032

出　　处：《时珍国医国药》2007年第1期83-85,共3页Lishizhen Medicine and Materia Medica Research

摘　　要：目的观察动物ig止嗽立效胶囊的急性毒性和长期毒性。方法ig小鼠作急性毒性实验,观察中毒症状并测定LD50及95%平均可信限。以1.5,3.0,6.0 g.kg-1.d-1(临床人用量60,120,240倍)ig大鼠连续6周,观察大鼠的生长发育、血液学、血液生化学、脏器指数、组织病理学变化及停药2周后上述指数的变化。结果小鼠ig LD50为17.4 g.kg-1(胶囊),87.6 g.kg-1(生药)。长期ig中、高剂量可抑制雄性大鼠体重增长,低、高剂量组雌性大鼠脾脏重量减轻,低剂量组雌性、高剂量组雄性大鼠胸腺重量减轻。对各剂量组大鼠血液学有一定影响。其它指标均无明显异常。结论止嗽立效胶囊具有一定毒性。Objective To observe the acute toxicity of Zhisoulixiao Capsule （ZC） in mice and its long - period toxicity to rats. Methods The acute toxicity experiment was done. The symptoms of ZC in mice were observed and 50 percent lethal dose（ LD50 ） was calculated. Three groups of rats （ in high, moderate and low dosage of ZC） were administered with repeated gastric infusion of ZC for 6 weeks. Body weight, hematological and hernatobiochemical parameters, coefficient and hisromorphological figure of organs（ the heart, liver, spleen, lungs, kidneys, adrenals, thymus, brain） were examined in 6 weeks and 2 weeks after cessation of ZC. Results The LDso of ZC was 17.4 g/kg by gastric infusion in mice. The body weight of male rats increased slowly in high - dosage and moderate - dosage groups. The coefficient of spleen decreased in low - dosage female group and high - dosage female group. The coefficient of thymus decreased in low - dosage female group and high - dosage male group. ZC had a certain effect on hematology. Conclusion ZC has certain toxicity.

关 键 词：止嗽立效胶囊 药理学 毒性 

分 类 号：R285.5[医药卫生—中药学]