苦碟子注射液对急性心肌缺血的保护作用  

The Protective Effect of Kudiezi Injection on the Experimental Acute Myocardial Infarction

作　　者：周晓棉[1] 金文淑[2] 曹春阳[3] 曹颖林[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016 [2]通化万通药业股份有限公司,吉林通化134001 [3]沈阳市红十字会医院,辽宁沈阳110013

出　　处：《时珍国医国药》2007年第1期122-123,126,共3页Lishizhen Medicine and Materia Medica Research

摘　　要：目的考察苦碟子注射液对实验动物急性心肌缺血的保护作用。方法采用异丙肾上腺素、垂体后叶素造成大鼠心肌缺血模型及结扎冠脉造成麻醉犬心肌缺血模型考察苦碟子注射液对心肌缺血的保护作用。结果苦碟子注射液以3.5,7.0,14.0 g.kg-1连续7 d腹腔注射给药可显著改善异丙肾上腺素、垂体后叶素造成大鼠心肌缺血;1.0,2.0,4.0 g.kg-1单次静脉注射给药明显降低结扎冠脉麻醉开胸犬的心肌梗塞面积,降低血清中乳酸脱氢酶(Lactic Dehydrogenase,LDH)、肌酸激酶(Creatine K inase,CK)活性;对冠脉结扎犬心外膜电图的S-T段偏也有显著改善作用(P<0.05或P<0.01)。结论苦碟子注射液对实验动物急性心肌缺血有显著改善作用。Objective To observe the protective effect of Kudiezi Injection （KDI） on dog and rat acute myocardial ischernia. Methods Rat acute myocardial isehemia model was induced by isoprenaline and hypophysin. Dog model was prepared by ligating the left anterior descending coronary artery. Results By intravenous injection（ 1.0,2.0,4.0 g · kg^-1） ,KDI decreased the activities of serum creatine kinase and lactic dehydrogenase, diminished the myocardial ischemia size and ∑-ST. By peritoneal injection for 7 days（ 3.5,7.0, 14.0g · kg^-1 ）, KDI strikingly improved acute myocardial ischemia by isoprenaline and hypophysin in rats （ P 〈 0.01 ）. Conclusion KDI is beneficial to experimental acute myocardial ischemia.

关 键 词：苦碟子注射液 异丙肾上腺素 垂体后叶素 心肌缺血 

分 类 号：R285.5[医药卫生—中药学]