西雅图量表评价血府逐瘀汤及其拆方治疗冠心病稳定性心绞痛的疗效观察  

Evaluation on Effects of Disassembled Formulas of Xuefu Zhuyu Decoction for Treatment of Angina Fectoris Using Seattle Angina Questionnaire

作　　者：荆鲁[1] 王阶[2] 王停[3] 

机构地区：[1]中国中医科学院西苑医院,北京100091 [2]中国中医科学院广安门医院 [3]国家食品药品监督管理局药品审评中心

出　　处：《中国中西医结合杂志》2007年第1期18-20,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家重点基础发展规划项目973计划:(No.2003CB517103)

摘　　要：目的观察西雅图心绞痛量表(西雅图量表)评价血府逐瘀汤及其拆方治疗冠心病稳定性心绞痛的疗效。方法123例冠心病稳定性心绞痛患者随机分为血府逐瘀组、精制血府逐瘀组、药对组、安慰剂组4组进行干预治疗,采用西雅图量表进行治疗前后疗效评价。结果血府逐瘀组治疗前后心绞痛稳定状态、心绞痛发作情况、治疗满意程度均较治疗前改善(P<0．05或P<0．01)。精制血府逐瘀组治疗后心绞痛稳定状态、心绞痛发作情况、治疗满意程度、疾病认知程度较治疗前改善(P<0．05或P<0．01)。药对组治疗后心绞痛稳定状态、心绞痛发作情况较治疗前改善(P<0．05或P<0．01)。安慰剂组治疗后心绞痛稳定状态较治疗前改善(P<0．05)。血府逐瘀汤及其拆方各组心绞痛发作情况改善优于安慰剂组(P<0．05)。结论西雅图量表评价血府逐瘀拆方治疗冠心病稳定心绞痛疗效,各拆方改善心绞痛发作情况优于安慰剂。Objective To evaluate the therapeutic effect of disassembled formulas of Xuefu Zhuyu Decoction （XZD） for treatment of angina pectoris （AP） of coronary heart disease （CHD） using Seattle Angina Questionnaire （SAQ）. Methods One hundred and twenty-three AP patients were randomly assigned to the XZD group, the refined XZD group, the drug-pair group and the placebo group. The therapeutic effect on scores in various aspects, including anginal stability （ Ⅰ）, anginal attack frequency （ Ⅱ ）, satisfaction on treatment （ Ⅲ ） and cognitive level on disease （Ⅳ） of patients was evaluated using SAQ before and after treatment. Results After treatment, improvement was shown on scores of Ⅰ , Ⅱ and Ⅲ in the XZD group, on those of all the four scores in the refined XZD group, on those of scores Ⅰ and Ⅱ in the drug-pair group and in the placebo group only on scores of Ⅰ was improved significantly （P 〈 0.05 or P 〈 0.01）. The improvement on scores of Ⅰ in the 3 treated groups was better significantly than that in the placebo group （P 〈 0.05）. Conclusion It is feasible to evaluate the therapeutic effect of disassembled formulas of XZD on AP of CHD with SAQ; XZD and its disassembled formulas shows better effects than that of placebo in improving the condition of angina attack.

关 键 词：西雅图量表 冠心病稳定性心绞痛 血府逐瘀汤拆方 

分 类 号：R259[医药卫生—中西医结合]