精制血府胶囊对股腘动脉人工血管旁路术后通畅率的影响  

Effects of Refined Xuefu Capsule on Vascular Patency Rate after Femoral-popliteal Bypass

作　　者：庄百溪[1] 马鲁波[1] 于春利[1] 张童[1] 杨淼[1] 石波 史大卓[1] 

机构地区：[1]中国中医科学院西苑医院,北京100091

出　　处：《中国中西医结合杂志》2007年第1期69-72,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察精制血府胶囊对下肢动脉硬化闭塞症(arteriosclerosis obliterans,ASO)患者股膕动脉搭桥后的临床疗效。方法选择股膕动脉搭桥ASO患者38例(41条患肢),随机分为对照组18例(20条患肢),中药组20例(21条患肢)。所有患者均予华法林长期口服抗凝治疗,中药组给予精制血府胶囊口服,疗程为3个月。观察临床症状、凝血功能的变化情况,超声检测治疗后6、12个月人工血管通畅情况及踝肱指数(anklc arm index,AAI)。结果手术后所有患者临床症状均明显改善。术后12个月间歇性跛行发生率中药组(20％,4／20例)较对照组(56％,10／18例)明显降低(P<0．05);截肢率中药组(5％,1／20例)低于对照组(17％,3／18例,P<0．05);术后12个月中药组人工血管通畅率(86％,18／21)较对照组(65％,13／20)显著增高(P<0．05);术后6个月、12个月中药组AAI(0．73±0．24、0．69±0．19)显著高于同期对照组(0．45+ 0．17、0．41±0．23,P<0．05)。结论精制血府胶囊可明显提高股膕动脉旁路术后12个月人工血管的通畅率,改善临床症状,缓解肢体缺血症状。Objective To observe the effects of refined Xuefu Capsule （RXC） in patients with arteriosclerosis obliterans （ASO） after femoral-popliteal bypass （FPB）. Methods Thirty-eight ASO patients with 41 limbs underwent FPB were randomly assigned to two groups： the control group （18 cases with 20 operated limbs） and the RXC group （20 cases with 21 operated limbs）. All patients received long-term anticoagulant treatment with Warfarin, and RXC was given to the RXC group additionally for 3 months. Changes of clinical symptoms, blood coagulating function, as well as the condition of vascular patency and ankle arm index （AAI） were assessed 6 and 12 months after operation. Results Clinical symptoms were improved in all the patients after operation. One year after operation, incidence of intermittent claudication and amputation rate in the RXC group was 20 % and 5%, being lower than the respective rate （56% and 17%） in the control group （P〈0.05）; the patency rate was 86% in the RXC group, being higher than that in the control group （65%, P〈0.05）. Six and 12 mouths after operation, AAI was 0.73 ± 0.24 and 0.69 ± 0.19 respectively in the RXC group, being significandy higher than that in the control group （0.45 ± 0.17 and 0.41 ±0.23, P〈0.05） at the corresponding time points. Conclusion RXC could obviously increase the patency rate 12 months after FPB, improve the dinical symptoms and alleviate the symptom of limb ischemia in ASO patients.

关 键 词：股腘动脉人工血管旁路术 下肢动脉硬化闭塞症 精制血府胶囊 

分 类 号：R285.5[医药卫生—中药学]