氯胺酮麻醉对犬脑功能影响的fMRI显像研究  

fMRI study on effect of ketamine on cerebral function in dogs

作　　者：孙绪德[1] 张惠 徐礼鲜 柴伟[1] 葛雅丽[3] 张劲松[3] 张贵和[1] 高昌俊[1] 韩丽春[1] 

机构地区：[1]第四军医大学唐都医院麻醉科,陕西西安710038 [2]第四军医大学口腔医院麻醉科 [3]第四军医大学西京医院放射科,陕西西安710033

出　　处：《第四军医大学学报》2007年第2期172-174,共3页Journal of the Fourth Military Medical University

基　　金：国家自然科学基金资助项目(30271257)

摘　　要：目的:应用磁共振成像技术,研究全麻药氯胺酮对犬脑磁共振信号强度变化的影响,探索麻醉药在脑内的可能作用部位.方法:刺激程序采用清醒-镇静-意识消失-苏醒的动态过程,扫描为60个动态.氯胺酮麻醉按2mg/kg通过采用恒速泵静脉注射,用药方式为输注.采用1.5TPhilipsGy-roscan磁共振系统,运用单次激发EPI扫描序列进行脑功能BOLD法成像并应用Functool软件进行功能分析.结果:氯胺酮麻醉可降低感觉皮层、运动皮层的信号强度,其r值分别为0.79,0.81,信号变化强度分别为19.5%,16.6%;丘脑和扣带回区信号也受到抑制,r值分别为0.66,0.68,信号变化强度为4.5%,4.7%.上述4个区域信号的抑制变化过程同步;皮层下其他区域包括海马基底节区未引出激活点.结论:氯胺酮麻醉抑制感觉皮层、运动皮层、丘脑和扣带回区域信号强度,而这些区域则可能是氯胺酮作用的靶位.AIM： To study the changes of NMR signal intensity in dog＇s cerebral regions after ketamine application, and to investigate specific brain regions that are sensitive to the anesthetic. METHODS： Stimulation procedure was performed from consciousness, to sedation, to unconsciousness, and finally to analepsia. Scan lasted 60 Dy. Ketamine was injected at a dose of 2 mg/kg with a constant speed infusion pump. Functional magnetic resonance imaging （fMRI） was applied during the entire experiment. A dynamic single-shot EPI sequence was used to perform BOLD functional MR imaging on a 1.5T Philips Gyroscan MR system and the Functool software was also used to analyze these images. RESULTS： For the ketamine anesthesia groups, the decreased signal intensity was observed at sensory cortex （ r = 0.79, 19.5% ）, at motor cortex （r = 0.81, 16.6% ）, at thalamus （r = 0.66, 4.5% ）, and at callosal gyrus （ r = 0.68, 4.7% ）. The changes of signal intensity were synchonous. However, there was no significant change in other subcortex regions. CONCLUSION： Ketamine anesthesia suppressed such regions as sensory cortex, motor cortex, thalamus and callosal gyrus, which might be the key targets for ketamine action.

关 键 词：氯胺酮 磁共振成像 麻醉 脑 

分 类 号：R614.24[医药卫生—麻醉学]