人精子膜功能完整性与精液参数的关系  

Relationship between the functional integrity of human sperm membrane and seminal parameters

作　　者：郭航[1] 郑海筝[2] 王瑞雪[2] 刘睿智[2] 

机构地区：[1]吉林大学第二临床医院泌尿外科,吉林长春130021 [2]吉林大学基础医学院细胞生物学教研室,吉林长春130021

出　　处：《基础医学与临床》2007年第1期53-56,共4页Basic and Clinical Medicine

基　　金：吉林省科技厅资助项目(200505140)

摘　　要：目的探讨精子膜功能完整性与精液参数的关系。方法收集503例精液样本,其中对照组149例,不育组354例。根据WHO标准分析精子密度、活率、活力、精液白细胞浓度、精子形态和精子尾部低渗膨胀(HOS)率。结果不育组精子尾部低渗膨胀率显著低于对照组(P<0.05)。与对照组相比,HOS正常不育组和HOS异常不育组形态正常精子率、密度、活力、活率均显著降低(P<0.05),头部异常精子率、精液白细胞浓度显著增高(P<0.05);此外,HOS正常不育组的尾部异常精子率显著高于对照组,其精子活力、活率均显著高于HOS异常不育组(P<0.05)。精子HOS与精子密度、活力、活率呈显著正相关,与精液白细胞浓度呈显著负相关(P<0.05)。结论精子膜功能可能与精液参数密切相关,精子膜功能是评价男性生育力的重要指标。Objective To study the relation between function of sperm membrane and seminal parameters. Methods Five hundred and three semen samples were collected from 149 normal men and 354 infertile men. Sperm concentration, motility, viability, semen WBC concentration, morphology and sperm tail hypo-osmotic swelling （HOS） were analyzed according to WHO criteria. Results Sperm HOS score in infertile group was lower than that in control group （ P 〈 0. 05 ）. Comparing with control group, the percentage of the concentration, motility, viability, as well as the percentage of sperm with normal morphology were significantly decreased in the normal and the abnormal HOS score infertile group, however, the rate of Head defects sperm and semen WBC concentration were significantly increased in these two groups（ P 〈 0. 05 ）. In addition, the rate of tail defects sperm in normal HOS score infertile group was higher than that in control group （ P 〈 0. 05 ）. Comparing with abnormal HOS scores infertile group, sperm motility, as well as sperm viability, was significantly decreased in normal HOS score infertile group （P 〈 0. 05 ）. Significant positive relationship of sperm HOS score was observed for sperm concentration, motility and viability （ P 〈 0. 05 ）. There was negative relationship between sperm HOS scores and semen WBC concentration （P 〈 0. 05 ）. Conclusion An important relationship is found between functional integrity of sperm membrane and semen parametem. Detection of sperm membrane function plays a key role in evaluation of male fertility.

关 键 词：精子膜功能 完整性 精液参数 

分 类 号：R446.1[医药卫生—诊断学]