纳米羟基磷灰石/聚酰胺多孔支架材料的制备及其结晶行为研究  

Preparation and crystallization behavior of nano-hydroxyapatite/polyamide6 (n-HA/PA6) scaffold

作　　者：程琳[1] 李玉宝[1] 左奕[1] 王华楠[1] 王园园[1] 李鸿[1] 

机构地区：[1]四川大学分析测试中心纳米生物材料研究中心

出　　处：《功能材料》2007年第1期47-49,52,共4页Journal of Functional Materials

基　　金：国家重点基础研究发展计划(973计划)国际合作资助项目(中荷战略联盟项目)(2004CB720604)

摘　　要：以NaCl为致孔剂，采用粒子沥滤-相转移法制备了纳米羟基磷灰石／聚酰胺6（n-HA／PA6）多孔支架材料，用扫描电子显微镜（SEM），X射线衍射（XRD），示差扫描量热仪（DSC）等对其进行表征。结果表明，用该方法制备的多孔支架孔径分布在50～300μm，孔隙率约为77％，孔与孔之间的贯通性良好。用粒子沥滤-相转移法制备的支架中PA6的晶胞体积较制备前有所增大，同时其结晶度也有增加。研究表明，NaCl粒子的存在促进了PA6聚合物晶体的生长。在制备成支架后，n-HA／PA6复合材料中PA6仍为混晶型高聚物，其晶型部分发生了转变，由制备前α晶型占多数变成了制备后γ晶型占多数。支架的制备过程使PA6更容易结晶，但结晶总速率在制备支架前后均没有太大改变。A novel porous scaffold of nano-hydroxyapatite and polyamide6 for tissue engineering was made by a method of phase separation and particle leaching combined （PS/PL）, NaC1 and alcohol were used as pore forming agent. Scanning electron microscope （SEM）, X-ray diffraction （XRD） and differential scanning calorimetry （DSC） were used to characterize the composite and scaffolds respectively. The results show that the scaffolds prepared have open and interconnecting porous structure with a pore size of 50-300μm and a porosity of about 77%. The cell size of PA6 crystal and the crystallization grade of PA6 increase during the formation of scaffolds at the same time, and NaCl particles promote the growth of PA6 crystal. The PA6 crystal type changes when scaffolds form, and the relative content of 7 crystals increase. The process of preparing the scaffolds promotes the crystalization of PA6 crystal, but dose not influence the velocity of PA6 crystal forming.

关 键 词：纳米羟基磷灰石 聚酰胺6 多孔支架 粒子沥 滤相转移 晶型转变 

分 类 号：TB39[一般工业技术—材料科学与工程]