早期肠内营养对肝移植术后肠黏膜屏障的影响  

Effects of early enteral nutrition on the gut barrier function for patients after liver transplantation

作　　者：张霁[1] 任辉[1] 

机构地区：[1]解放军第三军医大学西南医院,重庆400038

出　　处：《护士进修杂志》2007年第1期10-11,共2页Journal of Nurses Training

摘　　要：目的探讨早期肠内营养对肝移植病人术后肠黏膜屏障的影响。方法用随机数排序分组法将实施原位肝移植术后32例病人随机分为早期肠内营养(EEN)组和全胃肠外营养(TPN)组,各16例,检测两组病人肠道pH值及菌种比例、血浆内毒素、D-乳酸水平的变化。结果EEN组肝移植术后肠道pH值和革兰氏阴性肠杆菌比例明显低于TPN组:EEN组手术后3、57、d血浆内毒素和D-乳酸水平较TPN组低,两组比较均有显著性差异,P<0.05或P<0.01。结论肝移植术后早期应用EEN,有助于维持肠道黏膜的正常结构,保护肠黏膜屏障,从而减少内毒素移位的发生。Objective To investigate the effect of early enteral nutrition on the gut barrier function for patients after liver transplantation. Method A randomized controlled clinical trial was conducted for comparing the role of early enteral nutrition group（EEN group） with total parenteral nutritional group（TPN group）among 32 patients after orthotopic flora,plasma endotoxin level and D-lactate in the two groups were measured and compared. Result The intes- tinal amount of E. coli decreased significantly in EEN group compared with TPN group. Plasma endotoxin level and D-lactate of the EEN group were lower than that of TPN group on t 3.5 and 7 days after liver transplantation. There were statistical difference between the two groups,P〈0.05 or P〉0.01. Conclusion EEN helps maintain gut mucosal barrier,protects gut barrier function,decreases endotoxin translocation in patients after liver transplantation.

关 键 词：肝移植 肠内营养 肠黏膜 

分 类 号：R473.6[医药卫生—护理学]