长期低铅染毒对大鼠心肌微粒体膜脂质过氧化影响  

Lipid peroxidation of myocardial microsome membrane in rats chronically poisoned with low levels of lead

作　　者：王桂兰[1] 刘双军 吕萍[1] 刘智敏[1] 

机构地区：[1]河北医科大学毒理教研室

出　　处：《卫生研究》1996年第5期265-267,共3页Journal of Hygiene Research

摘　　要：分别以醋酸铅（ＰｂＡｃ２）１０，３０和９０ｍｇ／（ｋｇ·ｄ）给雄性ＳＤ大鼠灌胃，连续９周，结果表明心肌微粒体膜（ＭＭＳ）Ｎａ＋，Ｋ＋－ＡＴＰ酶（Ｎａ泵）、超氧化物歧化酶活性、血锌含量降低，ＭＭＳ丙二醛、血和尿铅、胸主动脉Ｃａ２＋含量及ＭＭＳＣａ２＋－ＡＴＰ酶（Ｃａ泵）活性增高，与对照组比较均呈显著性差异。离体大鼠ＭＭＳ单独与不同浓度（０．３，０．６，１．２ｍｍｏｌ／Ｌ）ＰｂＡｃ２共同温育后，除Ｃａ泵活性下降外，出现与体内同样毒性作用。ur study revealed the decrease of myocardial microsomes(MMS) Na +,K + ATPase activities, super oxide dismutase (SOD) activities and contents of blood zince, the elevation of malondialdehydo (MDA), Ca 2+ ATPase activities, levels of blood lead, urinary lead and calcium (Ca 2+ ) in thoracic aorta in male SD rats by repeative gavage at the doses of 10, 30 and 90 mg/(kg·d) lead acetatic (PbAc 2) for 9 weeks. The differences were significant between the experimental and control groups. The in vitro and in vivo tests showed the same results except the decline of Ca 2+ ATPase activities in vitro. The impairment of enzymes and the decline of anti LPO function of MMS play an important role in low dose lead induced myocardium toxicity.

关 键 词：醋酸铅 心肌 微粒体膜 脂质过氧化 

分 类 号：R992[医药卫生—毒理学] R135.11[医药卫生—药学]