Synthesis and Evaluation of PDE5 Inhibitory Activity of Novel Pyrido[2＇,1＇：5,1]pyrazolo[4,3-d]pyrimidin-4-one Derivatives  

作　　者：田广辉 夏广新 金薇西 陈新建 赖顺安 韦亚兵 嵇汝运 沈敬山 

机构地区：[1]Shanghai Institute ofMateria Medica, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, Shanghai 201203, China [2]Nanjing University of Technology, Nanjing, Jiangsu 210009, China [3]Topharman Shanghai Co., Ltd., Shanghai 201209, China

出　　处：《Chinese Journal of Chemistry》2007年第2期241-245,共5页中国化学（英文版）

摘　　要：Novel pyridopyrazolopyrimidinone derivatives were designed and synthesized as potential PDE5 inhibitors. The target compounds demonstrated significant inhibitory activity against human platelet PDE5, but less potent than sildenafil.Novel pyridopyrazolopyrimidinone derivatives were designed and synthesized as potential PDE5 inhibitors. The target compounds demonstrated significant inhibitory activity against human platelet PDE5, but less potent than sildenafil.

关 键 词：pyridopyrazolopyrimidinone PDE5 inhibitor SILDENAFIL 

分 类 号：O63[理学—高分子化学]