呋喃妥因的合成新工艺  

Synthesis of Nitrofurantoin

作　　者：吴修艮[1] 高瑞银[1] 陈进[1] 王慧[1] 程玉水 

机构地区：[1]江苏吉贝尔药业有限公司,镇江212009 [2]济南金达药化有限公司,济南250100

出　　处：《齐鲁药事》2007年第1期43-44,共2页qilu pharmaceutical affairs

摘　　要：目的确定一种新的呋喃妥因合成工艺.方法以糠醛、1-氨基海因盐酸盐、浓硫酸、硝酸为原料,选择适当的混酸浓度,并用DMF重结晶制得呋喃妥因.结果符合《中国药典》2005年版质量要求.结论本工艺收率较高,成本相对较低,产品质量稳定并符合法定标准.OBJECTIVE To establish a new synthetic route of Nitrofurantoin, METHODS Nitrofurantoin was used furfural, 1-aminohydantoin hydrochloride,concentrated sulfuric acid and nitric acid as raw material,and choose a suitable concentration of the mixed add,then recrystallized with DMF, RESULTS The product quantity complied C. P. 2005. CONCLUSION The method has a high yield and a low cost,The product quantity is stable and complied the lawful standard.

关 键 词：呋喃妥因 抗菌药 合成 1-氨基海因盐酸盐 糠醛 

分 类 号：TQ460.31[化学工程—制药化工]