O-磷酸-L-丝氨酸及其衍生物的合成  

Synthesis of O-Phospho-L-serine and Its Derivatives

作　　者：张建臣[1] 曹书霞[2] 赵军峰[2] 廖新成[2] 赵玉芬[2] 

机构地区：[1]北京防化指挥工程学院化学防护系,北京102205 [2]郑州大学有机化学及化学生物学重点实验室,郑州450052

出　　处：《有机化学》2007年第2期218-221,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20132020)资助项目.

摘　　要：介绍具有重要药理和生物活性的O-磷酸-L-丝氨酸及衍生物的合成.O-磷酸-L-丝氨酸通过部分水解的三氯氧磷与L-丝氨酸反应制得,并培养得到了其晶体,利用X射线衍射方法测定了它的晶体结构;进而合成了O-磷酸-L-丝氨酸钙盐和O-磷酸-L-丝氨酸单(或双)二异丙胺盐.产物经核磁共振、红外光谱和质谱进行了结构表征.O-Phospho-L-serine and its derivatives, having important pharmacology activity and bioactivity, were synthesized by the reaction of phosphorusoxychloride partially prehydrolyzed and L-serine. The crystal of O-phospho-L-serine was incubated and the crystal structure was determined by X-ray single crystal dif- fraction method. Furthermore, calcium salt, diisopropylamine salt and di（diisopropylamine） salt of O-phospho-L-serine were also synthesized. The structures of products were identified by NMR, IR and MS spectra.

关 键 词：L-丝氨酸 O-磷酸-L-N氨酸 合成 衍生物 

分 类 号：O621.2[理学—有机化学]