血清新喋呤检测在重症急性胰腺炎患者中的价值  

The value of serum neopterin determination in patients with severe acute pancreatitis

作　　者：王丽芳[1] 李永军[1] 张晋霞[1] 郝冀洪[1] 

机构地区：[1]河北医科大学第二医院检验科,河北石家庄050000

出　　处：《检验医学》2007年第1期1-3,共3页Laboratory Medicine

摘　　要：目的探讨血清新喋呤检测在重症急性胰腺炎(SAP)患者中的预警价值。方法急性胰腺炎患者77例,根据疾病的严重程度分为SAP 32例和轻症急性胰腺炎(MAP)45例。对照组40名。所有患者于发病入院后次日清晨空腹静脉采血,分离血清测定新喋呤含量。同时监测患者生命体征、血气分析、血常规及反映肝、肾、心等器官功能损害的生化指标的改变,并记录24 h APACHE II评分。结果MAP患者血清新喋呤水平与对照组比较差异无统计学意义,而SAP患者显著高于对照组(P<0.05)及MAP患者(P<0.01);重症组中死亡与存活者之间血清新喋呤水平差异有统计学意义(P<0.01),与病情危重程度有关。结论SAP患者血清新喋呤水平升高,并与疾病的严重程度呈正相关;检测SAP患者血清新喋呤水平有助于判断病情轻重及预后,对早期采取措施、改善预后有重要意义。Objective To investigate the predictive value of serum neopterin for patients with severe acute pancreatitis（SAP）. Methods 77 patients with acute pancreatitis （AP） were divided into mild group （32 cases） and severe group （45 cases） according to the severity of disease. 40 healthy peoples was control groups. Blood samples were obtained within 24 h after the onset of disease. The levels of serum neopterin were determined and APACHE Ⅱ scores were assessed for the patients in the first 24 hours. Results Within 24 h after the onset of AP the level of neopterin in patients with severe disease were significantly higher than that in patients with mild disease （ P 〈 0.05 ） and controls （ P 〈 0.01 ）. However, there was no significant difference between patients with mild AP and controls. In addition, the levels of neopterin in patients with fatal outcome were much higher than those in surviving patients （P 〈 0.01 ）. Conclusions The levels of neopterin in patients with SAP were increased and positively correlated with disease severity. The determination of neopterin can be useful in the observation of disease severity and prognosis.

关 键 词：新喋呤 重症急性胰腺炎 预警价值 

分 类 号：R446.1[医药卫生—诊断学]