手术创伤与血浆内皮素和降钙素基因相关肽水平相关性的临床研究  

Effects of operation wound on both endothelin and calcitonin gene-related peptide in hematoplasma of patients

作　　者：朱良红[1] 程光华[2] 张新路[2] 

机构地区：[1]皖南医学院附属弋矶山医院急诊外科 [2]皖南医学院附属弋矶山医院核医学科

出　　处：《中国临床药理学与治疗学》2006年第12期1420-1422,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:观察手术创伤与患者血浆内皮素(en-dothelin,ET)、降钙素基因相关肽(calcitoningene-re-latedpeptide,CGRP)水平的相关性。方法:对30例经受Ⅲ类手术患者、15例经受Ⅳ类手术患者手术前后的血浆内皮素与降钙素基因相关肽含量进行测定。结果:45例患者手术后血浆ET与CGRP含量较术前均显著升高(P<0.01),Ⅲ类、Ⅳ类手术患者术后血浆ET含量变化值比较无统计学意义,Ⅳ类手术患者CGRP含量变化值显著高于Ⅲ类手术患者(P<0.05)。结论:手术创伤可使血浆ET与CGRP含量升高,CGRP含量升高程度与手术创伤程度大小有关。AIM： To investigate the effects of major operation wound on both endothelin （ET） and calcitonin gene-related peptide （CGRP） in hematoplasma of patients. METHODS： We measured both endothelin and caleitonin gene-related peptide in hematoplasma during perioperative period for 30 patients who underwent Ⅲ category operation and for 15 patients who underwent Ⅳ category operation. RESULTS： After operation, ET and CGRP in hematoatoplasma of both groups who underwent Ⅲ category and Ⅳ category operation were significantly increased compared with those before operation （P 〈0.01）; ET in hematoplasma after operation was not statistically significant between the two groups. CGRP in hematoplasma after operation in the group who underwent Ⅳ category operation was increased markedly vs the group who underwent Ⅲ category operation （P 〈 0.05 ）. CONCLUSION： Operation wound can increase ET and CGRP in hematoplasma, and the extent of increasing CGRP is probably related to that of operation wound.

关 键 词：手术创伤 内皮素 降钙素基因相关肽 

分 类 号：R619.5[医药卫生—外科学]