CCK受体基因多态性及与部分精神疾病症状的相关性  

Polymorphisms of cholecystokinin receptor gene and its correlation with certain psychiatric disorders

作　　者：张璐[1] 王保捷[1] 丁梅[1] 

机构地区：[1]中国医科大学法医学院法医血清学教研室,辽宁沈阳110001

出　　处：《中国法医学杂志》2007年第1期39-42,共4页Chinese Journal of Forensic Medicine

基　　金：辽宁省教育厅高等学校科研项目计划(编号:2004D052)

摘　　要：胆囊收缩素(CCK)不仅存在于消化系统,而且还广泛存在于中枢及外周神经系统,并以神经递质的形式通过其受体(CCK-R)发挥着重要的生理作用。CCK-R有两种类型,CCK-AR和CCK-BR。CCK-R基因具有遗传多态性,并通过影响或改变CCK对中枢神经系统的作用强度而与酒精中毒、精神分裂症、恐慌症等人类精神疾病密切相关。CCK-R基因遗传多态性的研究可能为法医学个人识别与亲权鉴定新提供新的遗传标记及为司法精神病鉴定提供参考性遗传学指标。Cholecystokinin （CCK） is found not only in the digestive system, but also in the central and peripheral nervous system. As a neurotransmitter, it plays an important physiological role. Two CCK receptors, CCK-A receptor （CCK-AR） and CCK-B receptor （CCK-BR） have been identified. CCK receptor gene reveals polymorphism, and is closely associated with some psychic diseases, such as alcoholism, schizophrenia, and panic disorder, by influencing or changing the roles of CCK on CNS. CCK receptor gene polymorphismcan may serve as a new genetic marker for forensic individualization, parentage testing and foevaluation of psychiatric status.

关 键 词：法医物证学 胆囊收缩素受体 中枢神经系统 多态性 精神病 

分 类 号：D919[医药卫生—法医学]