RhoA在子痫前期患者胎盘中的表达  

Expression of RhoA in placenta of preeclampsia

作　　者：周丽[1] 乔福元[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,武汉430030

出　　处：《现代妇产科进展》2006年第12期924-925,929,共3页Progress in Obstetrics and Gynecology

摘　　要：目的:检测正常晚期妊娠和子痫前期患者胎盘RhoA的表达,探讨RhoA在子痫前期发病中的作用。方法:用免疫组织化学SP法及RT-PCR检测40例子痫前期和20例正常晚期妊娠胎盘RhoA蛋白及其mRNA的表达。结果:RhoA主要在滋养细胞表达。轻度子痫前期组和重度子痫前期组RhoA蛋白及mRNA均高于正常晚期妊娠组,差异有统计学意义(P<0.05)。结论:子痫前期患者胎盘RhoA的高表达可能与子痫前期的发病有一定的关系。Objective： To detect the expression of RhoA in placenta from normal pregnancy and preeclampsia. To evaluate the role of RhoA in preeclampsia. Method： The expression of RhoA in placenta collected from 40 preeclampsia patients and 20 normotensive controls was determined by immunohistochemistry and RT-PCR. Results： RhoA was found in syncytiotrophoblast and cytotrophoblast. The mean density of RhoA protein in placental tissues of mild and severe preeclampsia groups was significantly higher than that in normal pregnancy group. The expression level of RhoA mRNA in mild preeclampsia group and severe preeclampsia group was significantly higher than those from normal pregnancies. Conclusion： Increased expression of RhoA in placental tissues may play an important role in the pathogenesis of preeclampsia.

关 键 词：子痫前期 RHOA 胎盘 

分 类 号：R714.244[医药卫生—妇产科学]