重叠综合征  

Overlap syndrome

作　　者：杨秀云[1] 周建英[1] 

机构地区：[1]浙江大学医学院附属第一医院呼吸内科, 杭州310003

出　　处：《国际呼吸杂志》2007年第2期146-149,共4页International Journal of Respiration

摘　　要：慢性阻塞性肺疾病（COPD）是一种以气流受限不完全可逆为特征的常见的慢性呼吸系统疾病。睡眠呼吸暂停低通气综合征（SAHS）也是一种具有潜在危险的常见病。故COPD与SAHS合并存在者即重叠综合征患者的概率相当高。COPD患者睡眠时显著的低氧血症和高碳酸血症发生于快动眼睡眠期。重叠综合征患者较单纯SAHS或COPD患者有更为严重的睡眠有关的低氧血症，表现出更为严重的肺功能损害和肺动脉高压。因此，重叠综合征患者的及时诊断和合理治疗具有重要临床意义。Chronic obstructive pulmonary disease （COPD） is one of common respiratory diseases that features incompletely reversible airflow obstruction. While sleep-apnea hypoventilation syndrome（SAHS） is also a kind of common diseases with latent risks. Therefore, the probability of overlap syndrome （coexistence of COPD and SAHS） is rather high. The patients with COPD often exhibit hypoxia and hyper-carbonic acidemia during rapid eye movement phase. More severe sleep-related hypoxemia, damaged pulmonary function and pulmonary artery hypertension are present in the patients with overlap syndrome than those with COPD or SAHS. In conclusion, prompt diagnosis and appropriate treatment bear great clinical significance for the patients with overlap syndrome.

关 键 词：慢性阻塞性肺疾病 睡眠呼吸暂停低通气综合征 重叠综合征低氧血症 

分 类 号：R563[医药卫生—呼吸系统]