瓜蒌甘草颗粒对流感病毒肺炎小鼠保护作用研究  

Protective Effect of Gualou Gancao Granules on Pneumonia Mice Infected Influenza Virus

作　　者：唐光华[1] 余如瑾[2] 姜良铎[3] 

机构地区：[1]广东省中医院ICU,广州510120 [2]国家食品药品监督管理局南方医药经济研究所,广州510080 [3]北京中医药大学东直门医院,北京100700

出　　处：《中药新药与临床药理》2007年第1期9-12,共4页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：首都医学发展科研基金资助(首都ZD199808)

摘　　要：目的观察瓜蒌甘草颗粒对流感病毒肺炎小鼠的影响。方法以小鼠经鼻吸入流感病毒亚洲甲型鼠肺适应株(FM1)复制小鼠病毒性肺炎模型,并用瓜蒌甘草颗粒进行治疗,设置利巴韦林对照组,观察其对病毒肺炎小鼠的死亡率、体重、肺指数及病毒血凝滴度的影响。结果瓜蒌甘草颗粒治疗组较模型组死亡率明显降低,平均生存天数明显延长,体重下降得到明显改善,肺指数和血凝滴度都明显降低。结论以清热化痰、解毒扶正为法的瓜蒌甘草颗粒治疗小鼠流感病毒肺炎疗效肯定。Objective To study the effect of Gualou Gancao Granules（GLGC） on influenza virus pneumonia mice. Methods The mice model of viral pneumonia was established by nose inhalation of influenza virus FM1. The treatment groups were administered GLGC with ribavirin served as control drug. The mortality , body weight, lung index , viral blood agglutination titer of influenza virus pneumonia mice were observed. Results Compared with the model group, GLGC can reduce the mortality of influenza virus pneumonia mice, prolong the average living days, inhibit the body weight decrease, and depress the lung index and viral titer distinguishingly. Conclusion GLGC, which derived from the therapeutic principle of clearing away heat- evil and eliminating sputum, has an affirmative effect on influenza virus pneumonia mice.

关 键 词：病毒性肺炎 流感病毒 瓜蒌甘草颗粒 药效学 

分 类 号：R285.5[医药卫生—中药学]