清开灵注射剂致过敏性休克流行病学特点研究  

Epidemiological Characteristics of Anaphylactic Shock Caused by Qingkailing Injection

作　　者：吴嘉瑞[1] 张冰[1] 

机构地区：[1]北京中医药大学,北京100102

出　　处：《中药新药与临床药理》2007年第1期74-77,共4页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家食品药品监督管理局药品评价中心项目(2005B0601)

摘　　要：目的探讨清开灵注射剂引起过敏性休克的原因与规律。方法通过检索1978～2005年医药学期刊,收集清开灵注射剂致过敏性休克病案66例,应用文献计量学方法对病例的流行病学资料进行分析。结果资料中,18～44岁的青年患者数量最多(40.91%);男性29例(44.62%),女性36例(55.38%);患者原发疾病中上呼吸道感染比例最高(75.76%);用药剂量多在20～40mL范围内;过敏性休克均发生在给药后30min内,其中68%发生在10min以内;66例病案中,有5例死亡,其余患者经及时抢救治疗均好转、痊愈。结论清开灵注射剂可引起较严重甚至危及生命的过敏性休克反应,其发生机制可能与患者体质、药物本身成分和辨证不准等因素有关。临床应用中当注意结合中医理论辨证施治,控制给药剂量,减少不必要的配伍联用,增强预防意识。Objective To investigate the causations and rules of anaphylactic shock caused by Qingkailing Injection. Method The analysis was conducted on 66 cases of anaphylactic shock caused by Qingkailing Iinjection collected from medical journals in 1978 - 2005 by epidemiology and bibliometrics methods. Results There were a large number（40.91% ） of young sufferers from age 18 to 44 in the cases reported. The male cases was 29 （44.62 % ） and the female cases was 36 （55.38 % ） in the 65 cases with gender recordation. In primary disease, the upper respiratory tract infection rate was up to the highest 75.76 %. The dosage of Qingkailing Injection was in the range of 20 - 40 mL, the occurrence of anaphylactic shock was commonly within 30 mins after injection, and 68 % was within 10 min. The anaphylactic shock patients were cured after emergency treatment except 5 were died. Conclusion Qingkailing Injection can induce dangerous even fatal anaphylactic shock, its mechanism may be related to the constitution of the patient, ingredient of the drug self and diagnosis warp. Treatment based on syndrome differentiation combined with traditional Chinese medicine theory, dosage control, unnecessary compatibility decrease, prevention consciousness should be pay more attention in the clinical application.

关 键 词：清开灵注射剂 过敏性休克 流行病学 

分 类 号：R285.6[医药卫生—中药学]