黄芩苷-铬(Ⅲ)配合物的合成与表征  

Synthesis and Characterization of Baicalin-Chromium(Ⅲ) Complex

作　　者：邓毅[1] 赵爱华[1] 尹龙萍[1] 邱明丰[1] 贾伟[1] 

机构地区：[1]上海交通大学药学院,上海200240

出　　处：《中国天然药物》2007年第1期38-41,共4页

摘　　要：目的合成和表征了一种新的黄芩苷-铬(Ⅲ)配合物,并研究了配合物的稳定性。方法配体黄芩苷溶于60%乙醇水溶液中,在pH=9的碱性条件下,加入三氯化铬,回流4h,生成目标化合物。用红外光谱、紫外光谱、元素分析和电感耦合等离子体发射光谱对配合物进行了表征,热分析对其物理性质进行了分析。结果合成的黄芩苷-铬(Ⅲ)配合物的分子式为Na2Cr(C21H16O11)2(OH)-.10H2O。且证实了该配合物在酸性条件下是稳定的。结论首次合成的黄芩苷-铬(Ⅲ)配合物有望开发成为潜在的降糖新药。AIM： To synthesize and characterize a novel complex of baicalin with chromium（Ⅲ）, and study the stability of the complex. METHODS： Baicalin was dissolved in 60% ethanol, and the reaction was taken under refluxing with pH 9. The complex was characterized hy IR and UV spectra, as well as elemental analysis and ICP. RESULT： The baicalin-chromium complex was obtained with molecular formula Na2Cr（ C21H16O11）2 （OH）^ -·10H2O and it was stable in the acidic condition. CONCLUSION： The baicalin-chromium complex has been firstly successfully synthesized as a promising hypoglycemic agent.

关 键 词：黄芩苷 三价铬 合成 表征 稳定性 

分 类 号：R284.3[医药卫生—中药学]