同时作为热种子和药物载体的生物陶瓷的研制  

Investigation on Porous Magnetic Bio-ceramic as both Thermoseeds and Drug Carrier

作　　者：何宝平[1] 杨家宽[1] 周敏[1] 

机构地区：[1]华中科技大学环境科学与工程学院,湖北武汉430074

出　　处：《玻璃与搪瓷》2007年第1期15-18,共4页Glass & Enamel

基　　金：华中科技大学校医工结合项目(A260J02)

摘　　要：通过烧结法制作了LiFe5O8-CaO-SiO2-P2O5系统多孔磁性生物陶瓷,并对该陶瓷进行模拟体液浸泡、药物负载和缓释实验、XRD分析、孔径分析和磁性能的检测。实验结果表明,通过涂层的方法可以改善陶瓷样品的生物性能。有生物涂层样品的比饱和磁化强度和矫顽力分别能够达到28.1 A.m2.kg-1,2.39×103A.m-1,可以作为癌症温热疗法中使用的热种子,该多孔陶瓷同时表现出良好的药物载体功能。Porous magnetic LiFesOs -CaO- SiO2 -P2O5 bio- ceramics were prepared by sintering method. Immersing in SBF （simulated body fluid） , drug loading and releasing experiments, the XRD analysis, pore distribution analysis, magnetometry test were carried out. The results of those experiments show that bio - activity of the ceramic samples can be improved by bioactive coating. Specific saturation magnetization and coercive force of the ceramic sample with bio - active coating can reach 28.1A·m^2·kg^-1,2.39×10^3A·m^-1, respectively, hence this ceramic can be used as good hyperthermia thermoseeds, and it can also work as drug cartier properly.

关 键 词：生物陶瓷 温热疗法 热种子 药物载体 

分 类 号：TQ174.759[化学工程—陶瓷工业]