三种血管舒张剂对慢性缺氧性肺动脉高压大鼠肺动脉收缩反应的比较  

Comparison of three vasodilators on contractile responses of pulmonary artery from chronically hypoxic pulmonary hypertensive rats

作　　者：袁本通[1] Jeremy PTWARD 

机构地区：[1]深圳市红十字会医院呼吸内科

出　　处：《中国药理学与毒理学杂志》1996年第3期189-192,共4页Chinese Journal of Pharmacology and Toxicology

摘　　要：观察了米力农（Ｍｉｌ），ｌｅｍａｋａｌｉｍ（Ｌｅｍ）和维拉帕米（Ｖｅｒ）三种血管舒张剂对前列腺素Ｆ２α（ＰＧＦ２α）所致缺氧２和４ｗｋ大鼠肺动脉和主动脉环收缩反应的影响．Ｌｅｍ（０．０１～１．０μｍｏｌ·Ｌ－１），Ｍｉｌ和Ｖｅｒ（均为０．１～１０．０μｍｏｌ·Ｌ－１）对主动脉和肺动脉都有明显的抑制作用，使ＰＧＦ２α引起的血管收缩反应曲线压低，ＥＣ５０显著增高（Ｐ＜０．００１），呈剂量相关关系．其抑制强度为Ｌｅｍ＞Ｍｉｌ＞Ｖｅｒ，缺氧前后顺序不变．无论缺氧前后，Ｌｅｍ和Ｖｅｒ对主动脉和肺动脉的抑制强度都较接近，Ｍｉｌ则在缺氧条件下。The effects of milrinone (Mil), lemakalim [Lem, ( ) 6 cyano 3,4 dihydro 2,2 dimethyl trans 4 (2 oxo 1 pyrrolidinyl) 2H benzo pyran 3 ol] and verapamil (Ver) against contraction of pulmonary artery ring (PAR) and aorta ring (AR) from chronically hypoxic rats (hypoxia 2 and 4 weeks) induced by prostaglandin F 2α (PGF 2α ) were studied in vitro . Lem (0.01 1.0 μmol·L 1 ), Mil (0.1 10.0 μmol·L -1 ) and Ver (0.1-10.0 μmol·L -1 ) could remarkably inhibit vasocontraction in both of AR and PAR, with the depression of contractile responses elicited by PGF 2α and obvious increase in EC 50 , in a dose dependent manner. Among three vasodilators the order of inhibitory strength was Lem>Mil>Ver and this order never changed whether in normoxic rats or in hypoxic rats. Furthermore, the inhibition strengths of Lem and Ver against contraction of PAR and AR induced by PGF 2α were similar in values, either before or after hypoxia. However, the inhibitory strength of Mil was selectively increased in chronically hypoxic PAR.

关 键 词：血管舒张剂 缺氧症 肺动脉高压 肺动脉收缩 

分 类 号：R543.205[医药卫生—心血管疾病]