白芍总甙对佐剂性关节炎大鼠关节损伤的保护作用  

Protective effect of total glucosides of paeony on joint damage in adjuvant arthritis rats

作　　者：王斌[1] 姚余有[1] 周爱武[1] 葛志东[1] 陈敏珠[1] 徐叔云[1] 

机构地区：[1]安徽医科大学临床药理学研究所

出　　处：《中国药理学与毒理学杂志》1996年第3期211-214,共4页Chinese Journal of Pharmacology and Toxicology

摘　　要：通过检测佐剂性关节炎（ＡＡ）大鼠不同时间非致炎侧足爪容积，血浆丙二醛（ＭＤＡ）含量红细胞超氧化物歧化酶（ＳＯＤ），全血谷胱甘肽过氧化物酶（ＧＳＨＰｘ）活性，以及腹腔巨噬细胞释放亚硝酸盐（ＮＯ－２）和肿瘤坏死因子（ＴＮＦ），研究了白芍总甙对关节损伤的保护作用．结果表明，白芍总甙５０ｍｇ·ｋｇ－１·ｄ－１ｉｇ×１４～２８ｄ对ＡＡ大鼠全程给药，不仅抑制足肿胀，而且降低ＡＡ大鼠过高的ＭＤＡ，ＮＯ－２和ＴＮＦ水平，同时还使其过低的ＳＯＤ和ＧＳＨＰｘ活性增高或恢复正常．相关分析结果提示，白芍总甙的抗关节炎作用与其降低脂质过氧化。The protective effect of total glucosides of paeony (TGP) on joint damage was studied by measuring the volume of non injected hind paw, plasma malondialdehyde (MDA) content, superoxide dismutase (SOD) activity of red blood cells, glutathione peroxidase (GSHPx) activity in blood, nitrite and tumor necrosis factor (TNF) released from peritoneal macrophages (PM Φ) of adjuvant arthritis (AA) rats in different periods. The results showed that treatments of AA rats with TGP (50 mg·kg -1 ·d -1 , ig×14-28 d) could not only markedly inhibit paw swelling in AA rats, but also down regulate their elavated MDA, nitrite and TNF contents as well as up regulate their diminished SOD and GSHPx activity to normal levels. Correlative analysis suggested that suppression of arthritis of TGP could be associated with its reduction of elevated lipid peroxidation and restoration of anti oxidative enzymes and the secretion of PM Φ.

关 键 词：皂甙 白芍 关节炎 佐剂诱发性 中草药 

分 类 号：R274.94[医药卫生—中西医结合] R285.5[医药卫生—中医骨伤科学]